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- Cascaded catalytic hairpin 3D DNA walker-assisted dual-targeting biomimetic sensor for intracellular microRNA imaging
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01152C, PaperLanlan Jia, Jialin Guo, Min Li, Tingting Zhang, Yihan Sun, Yuxin Chen, Xiaoyu Xie, Qi Hu
Accurate detection and imaging of microRNAs (miRNAs) in living cells are crucial for early cancer diagnosis and prognosis. Although previous studies have focused on developing efficient miRNA detection methods, exploring...
The content of this RSS Feed (c) The Royal Society of Chemistry - Triggering isothermal exponential amplification of microRNA via liposome fusion
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01087J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mamiko Tsugane, Kosuke Kato, Keisuke Shinohara, Tsutomu Okita, Reiko Sato, Hiroaki Suzuki
Lipid membrane vesicles serve as essential cellular compartments where diverse biochemical reactions are regulated through dynamic membrane remodeling, including vesicle fusion. Reconstructing these processes in vitro is cruc... - Advanced multimodal imaging: FLIM, PLIM, and FluoRaman enabled by novel diarylacetylene probes
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00953G, Paper Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Joshua G. Hughes, Dimitrios Tsikritsis, Alexandra E. Bailie, Camilla Dondi, Eva Dias, Helen H. Fielding, Natalie A. Belsey, Michael Shaw, Stanley W. Botchway, Carrie A. Ambler, John M. Girkin, David R. Chisholm
Integrated fluorescence, lifetime, and Raman imaging of solvatochromic diarylacetylene probes provides complementary insight ... - Creating taxonomically-informed metabolome libraries for any species using the pubchem.bio R package
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00914F, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Corey Broeckling
Annotation remains a significant challenge in metabolomics, in large part due to the enormous structural diversity of small molecules. PubChem represents one of the largest curated chemical structure databases, with...
The content of this RSS Feed (c) The Royal Society of Chemistry - AQbD-driven UHPLC method for simultaneous quantification of budesonide, glycopyrronium bromide, and salbutamol sulphate: a unified approach for inhalation product and bioanalytical applications
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01086A, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alessio Gaggero, Dalibor Jeremic, Anna Fedorko, Jesús Alberto Afonso Urich
Inhalation therapies often combine budesonide, glycopyrronium bromide, and salbutamol sulphate, necessitating analytical methods capable of their simultaneous quantification.
To cite this article before page numbers are assigned, use the DOI form ... - Recent Advances in MXene Nanozymes: Synthesis, Surface Modifications, Catalytic Properties, and Their Emerging Roles in Biosensing and Therapeutic Applications
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01137J, Tutorial ReviewHatem A. Al-Aoh, Chellasamy Panneerselvam, Asim M Alghamdi, Abdulrahman Alasmari, Zuhair M Mohammedsaleh
The present review highlights recent advancements and future prospects in the development and application of MXene-based nanozymes, emphasizing their potential in biosensing, therapeutics, and theranostics. Eco-friendly and scalable synthesis methods,...
The content of this RSS Feed (c) The Royal Society of Chemistry - Surface charge engineering enhances symmetry and reliability of nanopores formed via dielectric breakdown
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00882D, PaperGuohao Xi, Gang Hu, Jie Ma, Lingzhi Wu, Jing Tu
Variations in the electrical properties of modified layers induce distinct changes in electron cloud distribution.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A valence-state-defect–mediated copper nanocluster nanozyme with high peroxidase-like activity for multimodal colorimetric detection of mercury(II)
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01159K, CommunicationZhong-Xia Wang, Peng Shan, Ze-Yu Sun, Weijie Ding, Fen-Ying Kong, Heng-Ye Li, Wei Wang
CuNC-based nanozyme multimodal colorimetric mercury(II) sensing is reported for the first time, demonstrating portability, manipulation, and rapid, selective and sensitive signal response.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Liquid-Liquid Phase Separation-Assisted Raman Microscopy for Sensitive and Label-Free Analysis of Enzymatic Reactions and Protein-Small Molecule Interactions
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00973A, PaperLisa Kageyama, Shinya Tahara, Reona Tobita, Shinji Kajimoto, Takakazu Nakabayashi
Raman spectroscopy enables label-free and non-destructive structural analysis of biomolecules; however, its application is limited by the inherently weak Raman signals, which necessitate high concentrations of biomolecules for detection. In...
The content of this RSS Feed (c) The Royal Society of Chemistry - Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01114K, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zohreh Mirveis, Nitin Patil, Hugh J. Byrne
Understanding dynamic metabolic processes is central to elucidating cellular function and disease mechanisms.
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The content of this RSS Feed (c) The Royal Society of Chemistry - DNAzyme walker-driven, electrode-surface label/wash-free ultrasensitive ECL miRNA detection via ssDNA-enhanced peroxidase activity of g-C3N4 nanosheets
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01164G, PaperJingwen Wu, Changgang Pan, Li Wang, Yuefeng Li, Guo-Xi Liang
A DNAzyme walker-driven, label/wash-free ECL biosensor for miRNA detection. The cleavage of substrate strands by the target miRNA releases ssDNA, which dramatically enhances the peroxidase-like activity of g-C3N4, leading to high sensitivity.
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The content of this RSS Feed (c) The Royal So... - Anti-tumour and associated metabolic effects of repurposed afuresertib and taxifolin for glioblastoma treatment
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00461F, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rui Chen, Nurcan Gumus, Supisara Jearranaiprepame, Alison Whitby, Ruman Rahman, Dong-Hyun Kim
Treating patient-derived glioblastoma cells with repurposed afuresertib and taxifolin showed strong anti-tumour activities and distinctive metabolic disturbance. Created with BioRender.com.
To cite this article before page numbers are assigned... - On-chip filtration enrichment and ultrasensitive nanozyme-catalyzed colorimetric detection of Streptococcus pneumoniae in saliva samples
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00879D, PaperYuancheng Guo, Zhijie Tu, Hong Chen, Hongjuan Wei, Tianci Wang, Guohui Sun, Zhen Rong
Streptococcus pneumoniae (S. pneumoniae) is a major cause of respiratory infections, requiring rapid, sensitive, and accessible diagnostic tools for early intervention, especially in resource-limited settings. Herein, we developed a microfluidic...
The content of this RSS Feed (c) The Royal Society of Chemistry - From Design to Application: Developments and Challenges of Nanomaterial-Based Optical Biosensors for Salmonella Detection
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00910C, Tutorial ReviewBin Wang, Yuan Tian, Zerun Zhang, Tianhan Kai, Jun Xiang, Pian Wu, Ping Ding
Salmonella is a widely distributed foodborne pathogen that poses a serious threat to public health.Traditional detection methods suffer from limitations such as being time-consuming, complex, and reliant on expensive equipment,...
The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: Highly-selective and sensitive plasmon-enhanced fluorescence sensor of aflatoxins
- Analyst, 2025, Advance Article
DOI: 10.1039/D5AN90087E, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tetyana Sergeyeva, Daria Yarynka, Vitaly Lytvyn, Petro Demydov, Andriy Lopatynskyi, Yevgeny Stepanenko, Oleksandr Brovko, Anatoliy Pinchuk, Volodymyr Chegel
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The content of this RSS Feed (c) The Royal Society of Chemistry - A near-infrared benzothiazole-based fluorescent probe for selective detection of CORM-3 with large Stokes shift in living cells
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01196E, PaperLiqiang Yan, Junjie Yang, Yanxin Zhang, Ying Sun, Jianmei Zou
Carbon monoxide (CO) is a key signaling molecule in mammals, playing essential roles in cell protection, maintenance of cellular homeostasis, and exhibiting great therapeutic potential for various diseases. Moreover, dysregulation...
The content of this RSS Feed (c) The Royal Society of Chemistry - Advances in gene-targeted diagnostics for pathogenic Escherichia coli
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00836K, Tutorial ReviewLinlin Zhuang, Jiansen Gong, Mengling Zhu, Ying Zhao, Xue Lian, Chuang Zhou, Xia Cao, Yu Zhang, Qiuping Shen
This review provides a comprehensive overview of gene-targeted diagnostics for pathogenic Escherichia coli, covering nucleic acid hybridization, PCR-based methods, isothermal amplification, biosensors, sequencing technologies, and emerging assays.
To cite this article before page numbers are assigned, use the DOI form ... - Correction: High-sensitivity SpectroChip-integrated LFIA platform for rapid point-of-care quantification of cardiovascular biomarkers
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90088C, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cheng-Hao Ko, Wei-Yi Kong
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The content of this RSS Feed (c) The Royal Society of Chemistry - Portable smartphone assisted multi-color colorimetric sensor for the detection of mercury ions based on the peroxidase-like activity of platinum nanoparticles
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01167A, PaperShasha Wang, Huiqing Zhang, Li Wang, Chaonan Huang, Jiping Ma, Liyan Wang, Xiaoyan Wang, Lingxin Chen
An innovative multi-color colorimetric method integrated with smartphone detection was designed with great sensitivity and specificity for determination of mercury ions (Hg2+) in aqueous samples based on platinum nanoparticles (PtNPs)...
The content of this RSS Feed (c) The Royal Society of Chemistry - Advances and innovations in machine learning-based spectral detection methods for trace organic pollutants
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00903K, Tutorial Reviewyiheng qin, Qiannan Duan, Haoyu Wang, yonghui bai, yihao qin, Liulu Yao, Fan Song, Mingzhe Wu, Jianchao Lee
The rapid and sensitive detection of trace organic pollutants in water is crucial for ensuring environmental safety. Traditional detection methods struggle to meet the demands of large-scale, real-time, and on-site...
The content of this RSS Feed (c) The Royal Society of Chemistry - Flexible hydrogel sensor based on MoS2 for highly selective dopamine detection against catecholamine cross-interference
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01080B, PaperJianyu Liu, Xiaolei Gao, Weifang Ma, Liyuan Zhang, Xiaoming Wen, Ming Zhai, Guobi Chai, Wu Fan, Qidong Zhang, Ronghan Wei, Qiyan Wang
Real-time monitoring of dopamine (DA) is vital for understanding neurophysiological processes and diagnosing neurological disorders.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Chemical additives facilitate molecular weight characterization of underivatized dextran by high-resolution electrospray ionization mass spectrometry
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01066G, PaperYujia Ying, Jiangang Chen, Shaoping Li, Jing Zhao
Ionization is usually difficult for underivatized dextran. After adding chemical additives, large polysaccharide ions can be investigated and their fragments are highly related with the structures.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Design and synthesis of fluorescent probes specific for pantetheinase and their application in bioimaging
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00338E, PaperJiman He, Zhengmin Yang, Cunji Gao, Zhiwei Ouyang, Bingying Cao, Yaling Rao, Liangliang Xiao, Shulin Zhao, Jiangke Qin
The FNJ-PA probe interacts with Vanin-1, it can specifically recognize and cleave the amide bond of the probe, releasing the fluorophore FNJN to recover the fluorescence.
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The content of this RSS Feed (c) The Royal Society of Chemi... - A label-free approach to simultaneous determination of three endocrine disruptors in river water: angular sweep total fluorescence spectroscopy coupled to multi-way calibration
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00925A, PaperAnupama Vijayan, John Prakash
Three endocrine disruptors, BPA, CBZ and CBR, are detected in river water using a sustainable workflow combining single-step surfactant pretreatment, angular sweep fluorescence spectroscopy, and PLS-based modelling.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Pocket-sized lab: rapid screening of Fe(III), Na(I), and pyridoxamine via a smartphone-enabled fluorescent PAD
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00968E, PaperHeni Soni, Krushna Baraiya, Divyesh Chaudhari, Sahaj A. Gandhi, Pinkesh G. Sutariya
A smartphone-assisted fluorescent paper-based analytical device (PAD) for the on-site detection of Fe(III), Na(I), and pyridoxamine vitamin.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Precise Klebsiella pneumoniae carbapenem resistance prediction by Zn–Cu/MOF-embedded hybrid nanosheet-assisted carbapenemase activity analysis
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00967G, PaperChenyao Lin, Qiaoping Wu, Menglu Mao, Xuedan Qiu, Chuanfan Ding, Yinghua Yan, Dumei Ma, Qingcao Li
A novel GNP@Zn–Cu/MOF@Au nanocomposite enables rapid and sensitive detection of carbapenemase activity by MALDI-TOF MS, offering a promising tool for clinical antimicrobial resistance testing.
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The content of this RSS Feed (c) The Royal Society of C... - Liposome array on a power-free microfluidic device for analysis of nanopore formation
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01113B, PaperMaho Hosokawa, Yiting Zhang, Masaki Ohtawa, Naoki Sasaki
A power-free microchannel-based platform that can accommodate numerous liposomes enables real-time analysis of Amphotericin B-induced nanopore formation, providing a high-throughput tool for screening enhancers and inhibitors of drug activity.
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The content of this RSS Feed (c) The Royal Socie... - Detection of 2,4-Dichlorophenoxyacetic acid by smartphone- based fluorescence detection coupled with ImageJ analysis on a molecularly imprinted membrane/ carbon dots via Schiff-based method
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00842E, PaperMuhammad Sajjad, Wijitar Dungchai, Nisakorn Thongkon
The persistent presence of 2,4-dichlorophenoxyacetic acid (2,4-D) in aquatic ecosystems poses a significant risk to both environment and human health. This study presented a novel fluorescence-based sensor designed to detect...
The content of this RSS Feed (c) The Royal Society of Chemistry - Vibrational spectroscopy combined with chemometric approaches in bacterial studies: a review of recent advances and applications
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00802F, Tutorial ReviewMaryam Kazemi, Arash Mahboubi, Reza Jahani, Hamid Reza Moghimi
Vibrational spectroscopy combined with chemometrics is expected to provide a high-throughput and a more efficient analytical approach for handling bacterial infections as one of the leading causes of global mortality and public health challenges.
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The content of this RSS Feed ... - Identification of organochlorides in distilled fractions of plastic pyrolysis oil using GC × GC coupled with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS) and GC coupled with a halogen selective detector (GC-XSD)
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00852B, PaperBruno da Costa Magalhães, Pascal Pijcke, Niels Verhoosel, Philip Janssen, Cesare Benedetti, Matthijs Ruitenbeek, Georgios Bellos, Melissa N. Dunkle
A crude plastic pyrolysis oil was distilled into fractions with intervals of 50 °C. By combining different analytical capabilities, several organochlorides were speciated across the distilled fractions.
To cite this article before page numbers are assigned, use the DOI form of citation ab... - Single-molecule nanopore profiling of protein domain fragment dynamics and aggregation
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01140J, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dapeng Chen, Fei Zheng, Guangle Qin, Chaofan Ma, Wei Liu, Lichun Zou, Haiyan Wang, Jingjie Sha
Single-molecule nanopore profiling reveals voltage- and environment-dependent conformational dynamics, dimerization, and dissociation of SARS-CoV-2 nucleocapsid protein domain fragments, advancing nanopore-based protein domain analysis for a... - Protection-free fabrication of glycopolymer-decorated electrodes for label-free electrochemical detection of pathogenic bacteria
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01136A, CommunicationLucen Li, Qinhan Chen, Aobin Han, Qiaolin Guo, Minghui Wang, Wei Song, Jing Lin, Gefei Li
A protection-free interfacial glycosylation strategy was developed to fabricate glycopolymer-modified electrodes, enabling label-free detection of pathogenic bacteria down to 102 CFU mL−1 in real food samples.
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The content of this RSS Feed (c) The Ro... - A fast-responding dual-mode probe for colorimetric and turn-on fluorescence sensing of mercury(II) in water and living cells
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00908A, CommunicationYanxin Wu, Huiyuan Wang, Kai Wei, Chendong Ji, Meizhen Yin
A mercury-sensitive probe (Cy-M) exhibits high sensitivity, excellent selectivity, and low detection limits with rapid response times. Its dual-mode sensing enables naked-eye detection of Hg2+ and live-cell imaging via turn-on fluorescence.
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The content of this RSS Feed (c) The Roya... - Hydrazine oxidation on a single electrocatalytic nanoring
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00651A, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sakshi A. Ailawar, Guillermo Colón-Quintana, Thomas B. Clarke, Jeffrey E. Dick
The schematic illustrates the electrocatalytic oxidation of hydrazine (N2H4) on a gold nanoring electrode deposited on a kinetically inert planar electrode.
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The conten... - Integrated microfluidic platform for programmable multi-window DNA fractionation and in situ recovery
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01091H, PaperDongliang Li, Chunlei Yang, Leiyang Xu, Tao Zeng, Xiao Shi, Quanxin Yun, Yuliang Dong, Yuning Zhang
An on-chip MFIGE platform integrating programmable DNA size selection with in situ dual-membrane recovery, enabling multi-window, high-fidelity enrichment of long fragments in a closed, low-shear, automation-ready format for long-read sequencing.
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Th... - A fluorescence biosensor based on a cell-free transcription system for species-specific DNA sequence detection and seahorse product identification
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01099C, PaperLinyue Tang, Qian Xie, Ming Chen, Cuiying Lin, Fang Luo, Zhongqin Li, Zhenyu Lin
A fluorescent biosensor based on a cell-free RNA transcription system was developed for species-specific DNA sequence detection and seahorse product identification.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A reagent-centred thermal control system driven by a cascade temperature control algorithm for high-speed PCR
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00965K, PaperYuheng Luo, Wangyang Hu, Jiajia Wu, Baoce Sun, Gang Jin, Qiang Xu
Accelerating quantitative polymerase chain reaction (qPCR) without compromising analytical fidelity remains a significant challenge in molecular diagnostics, primarily due to the thermal lag between heating elements and reagents.
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The content of this RSS Feed (c) The Royal Society of... - Development of liquid biopsy for screening colorectal cancer through the combination of an antibody microarray-based metal-enhanced sandwich immunofluorescent assay of cytokines with machine learning
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01041A, PaperWanyu Zhang, Shasha Li, Xudong Sun, Zhenxin Wang
The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC).
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The content of this RSS Feed (c) The Royal Society of Chemistry - A practical guide to working with nanopipettes
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01128K, Tutorial Review Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dominik Duleba, Adria Martínez-Aviñó, Robert P. Johnson
This perspective provides a practical guide to nanopipette fabrication, filling, surface modification, and characterisation. Various tips are given to facilitate more efficient workflows and increase research quality and throughput.
To cite this article before page nu... - Computational and design of experiment strategies to improve differentiation and quantitation of trace-level cannabinoids by copper cationization paper spray mass spectrometry
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01073J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jindar N. S. Sboto, Chris G. Gill
Copper cationization with paper spray mass spectrometry is sensitive and specific for quantifying cannabinoids. Design of experiment and density functional theory provided optimal metal ion candidates and paper substrate preparation conditions.
To cite this article before page numbers are... - Dramatically enhancing electrochemiluminescence performance in the aqueous phase using naphthalene diimides with excellent electron-transfer capability and water solubility
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01074H, PaperDalong Xu, Yuqi Wang, Mingxiu Tian, Liuxiang Chen, Zhengang Han
Luminescent substances with superior electron transfer capability and excellent water solubility are ideal candidates for constructing high-performance electrochemiluminescence (ECL) sensors.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Electrochemical determination of copper in seawater based on a patch-type integrated electrode modified with gold nanoparticle-decorated carbon nanoflowers
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01083G, PaperShengjie Chu, Fei Pan, Yuxuan Zhang, Haitao Han, Dawei Pan, Xueping Hu
A patch-type integrated electrochemical sensor based on carbon nanoflowers/gold nanoparticles for determination of copper in seawater.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Progress of lateral flow assays for the detection of molecular and microbial species: From basic formats to microfluids, CRISPR and artificial intelligence
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00392J, Tutorial ReviewJamila Husain Kagdi, Vaibhavkumar Nandkishor Mehta, Sanjay Jha, Tae Jung Park, Hirakendu Basu, Suresh Kumar Kailasa
Lateral flow assays (LFAs) have garnered much interest in the biomedical and agricultural sciences because of their user-friendly design, quick turnaround times, minimal interference, affordability, and ease of use by...
The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: Utilizing quantum fingerprints in plant cells to evaluate plant productivity
- Analyst, 2025, 150,5568-5568
DOI: 10.1039/D5AN90080H, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Umadini Ranasinghe, Abigail L. Stressinger, Guangpeng Xu, Yasmin Sarhan, Fred Harrington, James O. Berry, Tim Thomay
The content of this RSS Feed (c) The Royal Society of Chemistry - Determination of veliparib metabolic stability in the human liver microsomes using a hydrophilic interaction UPLC-MS/MS quantitative method: greenness assessment with an in silico study for ADME, DEREK alarms and metabolic lability
- Analyst, 2025, 150,5501-5513
DOI: 10.1039/D5AN01132A, PaperMohamed W. Attwa, Ali S. Abdelhameed, Haitham AlRabiah, Adnan A. Kadi
Veliparib exhibited a relatively slow extraction ratio, with a low Clint of 22.23 mL min−1 kg−1 and a long t1/2 of 36.48 min. Minor replacements within the pyrrolidine ring (96%) in veliparib may increase the metabolic stability and safety profile.
The content of this RSS Feed (c) The Royal Society of Chemistry - Development of one-step magnetic assay for the detection of fentanyl
- Analyst, 2025, 150,5411-5416
DOI: 10.1039/D5AN00361J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Fabiana Grillo, Elena Piletska, Ewa Moczko, César Cáceres, Sergey Piletsky
A one-step magnetic fluorescence immunoassay enables sensitive and specific fentanyl detection in blood plasma with minimal handling and no cross-reactivity to related opioids.
The content of this RSS Feed (c) The Royal Society of Chemistry - Octahedral Ce-MOF as an electrochemical sensor for the detection of chloramphenicol
- Analyst, 2025, 150,5531-5537
DOI: 10.1039/D5AN01008J, PaperYuting Luo, Yiwei Sun, Haoxiang Wang, Yuyang He, Ruoyu Wang, Mengqi Lu, Yingong Wang, Xinlong Yan, Dongpo Xu
The electrochemical performance of Ce-MOF@Apta was evaluated by cyclic voltammetry and differential pulse voltammetry. Ce-MOF@Apta has a wide detection range (1 nM–10 mM), low detection limit, good selectivity, stability and reproducibility.
The content of this RSS Feed (c) The Royal Society of Chemistry - A sustainable and novel LC-TQ-MS/MS method for quantifying mutagenic Ketoconazole-NDSRIs aligned with green and white analytical chemistry principles
- Analyst, 2025, 150,5457-5472
DOI: 10.1039/D5AN01052G, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Srinivas Nakka, Vishnu Murthy Marisetti, Surendra Babu Manabolu Surya
Schematic work flow of Ketoconazole NDSRIs determination using LC-TQ-MS/MS.
The content of this RSS Feed (c) The Royal Society of Chemistry - Spatial distribution of differential metabolites in different parts of Curcuma phaeocaulis Val. using ultra-high-performance liquid chromatography-quadrupole Orbitrap high-resolution mass spectrometry and desorption electrospray ionization mass spectrometry imaging
- Analyst, 2025, 150,5538-5557
DOI: 10.1039/D5AN01077B, PaperYing Zhu, Chuyue Wu, Qinwan Huang, Jin Wang
Roots and rhizomes of Curcuma phaeocaulis Val. are used as distinct traditional Chinese medicines with a reported blood-circulating and stasis-removing effect.
The content of this RSS Feed (c) The Royal Society of Chemistry - An enzyme-free fluorescence biosensor for UO22+ detection using a four-leaf clover-shaped quadruple walker as a signal amplifier
- Analyst, 2025, 150,5525-5530
DOI: 10.1039/D5AN00920K, PaperNan Hu, Yimei Guo, Ying Zeng, Weichao Zhao, Dexin Ding, Jiafeng Pan, Junhua Chen
Based on four-leaf clover-shaped quadruple walking, an enzyme-free fluorescence biosensor was designed for ultrasensitive detection of UO22+.
The content of this RSS Feed (c) The Royal Society of Chemistry - Toward minimally invasive metabolomics: GC-MS metabolic fingerprints of dried blood microsamples in comparison to plasma
- Analyst, 2025, 150,5445-5456
DOI: 10.1039/D5AN00937E, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniel Marques de Sá e Silva, Marlene Thaitumu, Christina Virgiliou, Alexandra Tiganouria, Fernanda Rey-Stolle, Glykeria Avgerinou, Anatoli Petridou, Vasileios Mougios, Georgios Theodoridis, Helen Gika
The first comprehensive study comparing global metabolic profiles from three BµS devices against plasma and venous liquid blood using ... - Research progress of technology for exocytosis detection in the nervous system
- Analyst, 2025, 150,5379-5393
DOI: 10.1039/D5AN00934K, MinireviewFu-Li Zhang, Cheng-Bao Xu, Xiao-Ying Zhao, Shi-Yue Du, Jun-Ming Tang
We summarized the progress and application scenarios of common exocytosis detection methods, including brain microdialysis, novel imaging technology, fluorescent probes, and electroanalytical and electrophysiological methods.
The content of this RSS Feed (c) The Royal Society of Chemistry - Enhanced protein synthesis from immobilized circular DNA via triple-helix formation
- Analyst, 2025, 150,5403-5410
DOI: 10.1039/D5AN00995B, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shunsuke Takahashi, Kazuki Hayashi, Jun Okada, Hibiki Takashima, Koko Nakata, Masahiko Oshige, Shinji Katsura
Circular DNA immobilization via triplex formation onto streptavidin surfaces creates orientation-controlled templates. These templates yield approximately 4.6 times more protein than linear DNA in cell-free synthesis and can be ... - V-Ti3C2 nanozyme with peroxidase-like activity for dye removal and the colorimetric detection of Fe3+
- Analyst, 2025, 150,5514-5524
DOI: 10.1039/D5AN01014D, PaperFeng Yang, Congying Ding, Zihui Chen, Guoqing Zhao, Lamei Zhou, Wanqing Yue
Preparation of V-Ti3C2 and its application in dye adsorption and degradation, as well as Fe3+ detection.
The content of this RSS Feed (c) The Royal Society of Chemistry - Nondestructive multiparameter quantification of nanoporous films by broadband SPR/PWR spectroscopy
- Analyst, 2025, 150,5432-5444
DOI: 10.1039/D5AN00951K, PaperZiwei Liu, Xiumei Wan, Hongyi Tang, Zhi-mei Qi
Nondestructive measurement of film thickness (d) and porosity (P) is crucial for the rational design, controllable synthesis and accurate characterization of multifunctional nanoporous thin films (NPTFs).
The content of this RSS Feed (c) The Royal Society of Chemistry - Differentiation of different subtypes of polystyrene microplastics using Nile red
- Analyst, 2025, 150,5424-5431
DOI: 10.1039/D5AN00710K, PaperXiaoyan Hu, Chenfei Duan, Qiaocheng Feng, Heng Lu, Liangqia Guo
Five common subtypes of PS MPs were successfully differentiated via fluorescence imaging by controlling NR dyeing conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry - Synergistic coordination-driven ratiometric fluorescence detection of the anthrax biomarker dipicolinic acid
- Analyst, 2025, 150,5417-5423
DOI: 10.1039/D5AN00924C, PaperJunrong Wu, Qian Zhang, Xiaofeng Zhou, Jiaojiao Zhang, Liangquan Sheng, Huajie Xu, Fuying Hao, Zhaodi Liu
A novel ratiometric fluorescent nanoprobe was developed for the detection of the anthrax biomarker dipicolinic acid (DPA) in complex environments and on actual spores, based on the synergistic coordination of a terpyridine derivative and ZIF-8.
The content of this RSS Feed (c) The Royal Society of Chemistry - An automated illumination system for high-throughput photopharmacology studies: a case study of ROS-sensitive Zn- and Pd-phthalocyanine-loaded liposomes
- Analyst, 2025, 150,5473-5480
DOI: 10.1039/D5AN00927H, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ali Eftekhari, Olga Lem, Alexander Efimov, Timo Laaksonen, Nikita Durandin
An automated illumination system for high-throughput photopharmacology studies has been developed and validated.
The content of this RSS Feed (c) The Royal Society of Chemistry - Barium ion sensing with IPG K+ molecular probes
- Analyst, 2025, 150,5558-5567
DOI: 10.1039/D5AN00577A, PaperR. L. Miller, N. Byrnes, C. G. Cameron, A. J. Carlson, E. Dey, R. Madigan, J. Medina, S. Melancon, K. E. Navarro, F. W. Foss, B. J. P. Jones, C. Adams, H. Almazán, V. Alvarez, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, J. E. Barcelon, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodriguez, F. I. G. M. Borges, A. Brodolin, A. Castillo, E. Church, L. Cid, C. A. N. Co... - Utilizing quantum fingerprints in plant cells to evaluate plant productivity
- Analyst, 2025, 150,5394-5402
DOI: 10.1039/D5AN00326A, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Umadini Ranasinghe, Abigail L. Stressinger, Guangpeng Xu, Yasmin Sarhan, Fred Harrington, James O. Berry, Tim Thomay
A quantum fingerprint depicting photosynthetic productivity is developed from quantum light emitters, overcoming the limitations of plant autofluorescence.
The content of this RSS Feed (c) The Royal Society o... - Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS
- Analyst, 2025, 150,5374-5378
DOI: 10.1039/D5AN00152H, Communication Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zuzanna Szymańska, Magdalena Matczuk, Agnieszka Żuchowska, Paweł Romańczuk, Andrei R. Timerbaev, Maciej Jarosz
A tool to unravel the uptake diversity of cisplatin within a cancer cell population, based on SC-ICP-MS/MS and advanced data processing.
The content of this RSS Feed (c) The Royal Society of Chemistry - AQbD-based headspace GC-MS/MS method development under ICH Q14 guidelines for simultaneous analysis of residual solvents in pharmaceuticals
- Analyst, 2025, 150,5481-5500
DOI: 10.1039/D5AN00653H, PaperBontha Koteswaramma, Shubham Dhiman, Kalva Bhadrayya, Anupam Jana, Ramalingam Peraman
A risk assessment-driven Analytical Quality by Design (AQbD) approach was applied to develop and validate a headspace GC-MS/MS method for simultaneous quantification of residual solvent impurities (RSIs) in pharmaceutical drug substances.
The content of this RSS Feed (c) The Royal Society of Chemistry - H2O2-free colorimetric sensing platform of Mn-doped carbon dots with oxidase-mimetic activity for the detection of glutathione in liver disease serum
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00964B, PaperLin Bo, Lili Jiang, Zhaogui Deng, Minmin Xu, Yifei Liu, Hui Zhang, Xianwei Zuo, Haitao Yu
Schematic of the functional principle of the colorimetric detection of GSH with the oxidase-like mimetic activity of Mn-CDs.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90081F, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.R. González-Vegas, O. Seksek, A. Bertho, J. Bergs, R. Hirayama, T. Inaniwa, N. Matsufuji, T. Shimokawa, Y. Prezado, I. Yousef, I. Martínez-Rovira
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The content of this RSS Feed (c) The Royal Society of Chemistry - Ionic Liquid-based Dual-Mode Nano-optode for Ultra-Sensitive Detection of Perchlorate Ions
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01064K, PaperSubekchha Pradhan, Upika Darnal, Shraddha Rai, Subham Lama, Ashish Rai, Rifath Darjee, Najmin Tohora, Sabbir Ahamed, Sudhir Kumar Das
We introduced an orange light-emitting ionic liquid (IL), XBIL, and its dual-mode nano-optode, nXBIL, for selective detection of perchlorate(ClO₄⁻) ions. Comprehensive spectroscopic and microscopic analyses confirmed the structural integrity and...
The content of this RSS Feed (c) The Royal Soc... - Characterizing DPPM inhibition of butyrylcholinesterase: integrated enzymatic kinetics and Raman spectroscopy with chemometric analysis
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01018G, PaperAubrey Barney, Ashley Newland, Abraham Olayeri, Jan Halámek, Lenka Halámková
Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Sensitive detection and accurate bioimaging of circRNA based on sponge amplification using a DNA tetrahedral nanoprobe
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00611B, PaperGege Xie, Shengrong Yu, Rong Feng, Jingwen Chen, Yiming Wang, Haorong Liu, Yong-Xiang Wu, Shengjia Yu, Keqi Tang
Based on the miRNA sponge amplification property of circRNA, a novel fluorescent DNA tetrahedron nanoprobe (DTNP) was developed for highly sensitive detection and in situ bioimaging of circRNA in living cells.
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The content of this RSS Fe... - Boosting living Bacillus spore identification: Kolmogorov–Arnold network-guided convolutional neural network combined with laser tweezers Raman spectroscopy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00834D, PaperYifan Sun, Xiao Peng, Fusheng Du, Lin He, Yuan Lu, Yufeng Yuan, Junle Qu
As primary carriers of foodborne and zoonotic diseases, Bacillus spores can pose a serious threat to food microbiology and human disease.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Metabolic fingerprinting of periodontal bacteria: a multi-scale mass spectrometry and vibrational spectroscopy approach
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00507H, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jawaher Albahri, Daniel Smaje, Yun Xu, Steven Robinson, Heather Allison, Kathryn A. Whitehead, Howbeer Muhamadali
Periodontitis is a prevalent condition characterised by progressive destruction of the supporting periodontium around teeth, resulting from prolonged interaction between the host immune system and bacterial infection.
To ci... - Microanalysis of a single droplet produced by optical tweezers in an aqueous solution of bovine serum albumin
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01045D, PaperAyana Takayanagi, Yasuyuki Tsuboi, Ken-ichi Yuyama
We apply optical tweezers to form a single protein-rich microdroplet in a BSA–YCl3 solution, enabling precise in situ microscopic and microspectroscopic analyses through high spatial and temporal control of liquid–liquid phase separation.
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The content of this RSS Feed (c) The Royal Society of C... - Transition metal doping boosting paper-based photoelectrochemical immunosensing for neurofilament light chain protein detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01030F, PaperCheng-Hua Xu, An-Yang Tao, Mei-Qing Meng, Xi-Le Zhang, Cheng Fang, Feng-Zao Chen, De-Man Han
Early diagnosis of neurodegenerative diseases relies on highly sensitive detection of their specific biomarkers.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A DNAzyme amplifier-based immunoassay for small molecule detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01013F, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Han Pang, Qiang Zhao
A DNAzyme amplifier-based immunoassay for sensitive detection of small molecules is developed by using DNAzyme labeled small molecules and antibodies coated on microplates.
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The content of this RSS Feed (c) The Ro... - SpectralFlow: an integrated platform for spectral data preprocessing and predictive modeling analysis in fruit quality evaluation
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00794A, PaperZhikai Chen, Guanzhi Lyu, Xiaochan Wang, Mengfei Yang, Xin Xu, Xiaolei Zhang
An overview of SpectralFlow's features and two specific case demonstrations are presented.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Recent advances in fluorescence-colorimetric sensor arrays and their applications in biomedical fields
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00900F, Tutorial ReviewLiuwen Shao, Jiannan Liu, Xinxin Chen, Wenxiang Xiao
Fluorescence colorimetric dual-mode sensor arrays have drawn significant attention in biomedical analysis.
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The content of this RSS Feed (c) The Royal Society of Chemistry
