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Integration of Raman Tweezers and Machine Learning for Label-Free Single-Cell Characterization of Endometriosis Cells
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01076D, Paper
Hien Dinh Nguyen, N/A Asaduzzaman , Ajitesh Dhal, Bashir Danmahawayi Zubairu, Chang-I Chen, J. Timothy Qiu, Zhao-Chi Chen, Tzu-Sen Yang
Endometriosis occurs when endometrial tissue grows outside the uterus, affecting millions of women worldwide. Despite extensive research, its cellular mechanisms remain unclear, complicating both diagnosis and treatment. This study presents...
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An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor for highly sensitive detection of hypochlorous acid

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01299F, Paper
Xin Liu, Xiangyue Wang, Shaoying He, Mingxi Li, Chunhua Lu, Chao Xing
An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor was constructed for HClO detection.
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Structure-adaptive dual-function poly-T sequences enable homogeneous label-free colorimetric sensing platform
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01335F, Paper
Shao-Yu Sun, Yi Song, An-Qi Xiao, Xin-Yan Zhang, Xu-Xia Yan, Huidong Qiu, Qianyu Zhou
Compared with the extensive research on G-rich nucleic acids, the catalytic properties of T-rich sequences have received limited attention. Herein, the peroxidase-like activity of poly-T sequences was investigated, and the...
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Comparative Studies for Conventional and AI Methods for Sugar, Food, Textile, and Pharmaceutical Industries Wastewater Treatment: A Review
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00975H, Critical Review
Shagufta Jabin, Ritu Bir, Sadiqa Abbas, Jyoti Chawla, Anisha ., Sapana Jadoun
Industrial wastewater treatment in sectors such as food, sugar, textiles, and pharmaceuticals has attracted interest in the use of traditional methodologies in combination with Artificial Intelligence (AI). This combination of...
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Vibrational spectroscopy for rapid profiling of vancomycin susceptibility in Enterococci
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01068C, Communication
Ava Rossetti, xenia kostoulias, Magdalena Giergiel, Jhih-Hang Jiang, Anton Y Peleg, Kamila Kochan
Fast diagnosis of antimicrobial resistance (AMR), especially in high-priority pathogens, is essential to maintain the best-possible patient outcomes. In this communication, we present a new approach for rapid AMR assessment...
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MXene-based fluorescent aptasensors: advances and prospects in diagnostics and environmental monitoring

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00945F, Minireview
Open Access Open Access
Rajapriya Govindaraju, Jongsung Kim
MXene-based fluorescent aptasensors for diagnostics and environmental monitoring.
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Interrogating the existing analytical palette deployed for Leptospirosis detection and diagnostics
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00005C, Critical Review
Prasanna Kannan Embar, Prasanth Venkatachalam, Judy Gopal, Nazim Hasan, Manikandan Muthu
Though not very popularly recognised as a pathogenic disease, yet each year silently the morbidity and mortality of Leptospirosis has rapidly increased up to 1.03 million and 58,900 respectively. The...
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Improved NMR-based diffusion measurements for inorganic ions

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01232E, Paper
Maria Clara D. N. G. Leal, Binhan Yu, Tianzhi Wang, Junji Iwahara
The most widely used NMR method to measure diffusion is suboptimal for inorganic ions. A robust and superior alternative is available when strong field gradients (>1000 G/cm) can be used.
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Untargeted Mass Spectrometry to Investigate Ocean Acidification in Cancer borealis Using Optimized Metabolite Extraction methods
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00788G, Paper
Yunxiao Yao, Olga Riusech, Shuling XU, Lingjun Li
Ocean acidification (OA) refers to the ongoing decline in ocean pH caused by the cascading effects of increased atmospheric CO2, which has significant negative impacts on various marine organisms, particularly...
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Temporal SERS quantification and the chemometric monitoring of amikacin release in blood serum from a stimuli-responsive drug carrier: kinetics modeling and in-vitro pharmacodynamic evaluation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01153A, Paper
Anfal Fatima, Nasir Mehmood, Ali Akbar, Abdul Naman, Mohammed Alissa, Ghadah S. Abusalim, Adil Abalkhail, Minseok Kim
The controlled delivery of antibiotics from stimuli-responsive hydrogels is a promising approach, although controlled release kinetics and pharmacodynamic (PD) outcomes are very challenging to measure accurately.
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Recent advances in MXene nanozymes: synthesis, surface modifications, catalytic properties, and their emerging roles in biosensing and therapeutic applications

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01137J, Tutorial Review
Hatem A. Al-Aoh, Chellasamy Panneerselvam, Asim. M. Alghamdi, Abdulrahman Alasmari, Zuhair M. Mohammedsaleh
MXene nanozymes have emerged as an important class of nanomaterials, bridging materials science, chemistry, and biomedicine with their exceptional catalytic properties, tunable surface chemistry, and multifunctionality.
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Thermodynamic and Modeling Insights of DNA Molecular Beacons with Dual Target Binding to Design for Tunable Fluorescent Outputs
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01208B, Paper
Esther Emelia Stopps, Stephanie Ellen McCalla
Molecular beacons offer a versatile platform for detecting specific nucleic acid targets based on the relative proximity of fluorophore and quencher molecules. Conventional beacons contain a single target-binding site in...
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Integrated microfluidic device for rapid and accurate point-of-care detection of high-risk HPV16 and HPV18

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01244A, Paper
Natish Kumar, Monika Kumari, Devtulya Chander, Sandeep Dogra, Asha Chaubey, Ravi Kumar Arun
Integrated microfluidic LAMP-LFA  platform for on-chip HPV nucleic acid extraction, amplification, and lateral-flow detection.
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Ambient ionization strategies for the characterization of microbial systems via mass spectrometry

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01214G, Minireview
Open Access Open Access
Hawkins S. Shepard, Jody C. May, John A. McLean
This minireview focuses on the most important developments in the field of ambient ionization mass spectrometry applications to microbial samples reported in the last five years.
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T...
Quantification of buparlisib in human liver microsomes employing an ultra-fast, sensitive UPLC-MS/MS method: in vitro and in silico metabolic stability evaluation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01155H, Paper
Mohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi
Buparlisib exhibited a moderate extraction ratio, with a Clint of 32.24 mL min−1 kg−1 and a t1/2 of 25.15 min. Small changes of the 2-aminopyridine (58%) and morpholine (42%) moieties in buparlisib may increase stability and enhance safety profile.
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CRISPR/Cas13a-Induced Self-Priming Cyclic Amplification Enables Liquid Biopsy of Exosomal Circular RNA in Non-small Cell Lung Cancer
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01345C, Paper
Xiaodan Zhu, Guomin Gu, Yanli Shen, Mihray Abdurazik, Gang Sun
The precise and reliable identification of circular RNA (circRNA) is essential for both biological studies and clinical diagnostics of non-small cell lung cancer (NSCLC), especially the exosomal circRNA. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry
In situ synthesis of gold-core silver-shell nanoparticles on bacterial cellulose for SERS detection of micro- and nanoplastic particles in vegetables

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01043H, Paper
Open Access Open Access
Seyedehalaleh Kousheh, Azlin Mustapha, Mengshi Lin
Micro- and nanoplastic particles (MNPs) are ubiquitous environmental contaminants, raising significant concerns due to their potential health risks.
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Selective Thin-Film Microextraction of Naproxen from Biological and Environmental matrices utilizing Chitosan-Derived Bio-Imprinted Polymer with Fluorescence Detection
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00991J, Paper
Zahra Ayazi, samira pashayi sarnaghi, Mays Ali Hassooni Al-Najafi
This work presents selective isolation of naproxen (NAP) from complex matrices through the synthesis of a self-supporting chitosan-derived molecularly imprinted polymer (MIP) monolithic thin film as a tailor made adsorbent...
The content of this RSS Feed (c) The Royal Society of Chemistry
An electrochemical immunosensor based on MXene–Au and Au–Ce-COF to detect methyl parathion

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01289A, Paper
Peiyao Zhu, Deyu Liu, Yaqi Chen, Haiping Huang, Fang Xu
An electrochemical immunosensor based on MXene nanosheets loaded with AuNPs (MXene–Au) and a cerium-doped covalent organic framework loaded with AuNPs (Au–Ce-COF) was constructed and applied for the ultra-sensitive detection of methyl parathion.
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Selective Electrochemical Discrimination of 3’ IsomiRs Differing by Two Nucleotides
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01292A, Paper
Julio Ojeda, Nicholas Bruno, Karen Cover, Wencai Zhang, Karin Chumbimuni-Torres
MicroRNAs and isomiRs are promising biomarkers for the detection of diseases such as cancers, but distinguishing the highly similar microRNAs sequences between these remains challenging. We report a five-strand four-way...
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Anti-Interference Near-Infrared SERS Tag-Aptamer Sensor for Rapid Detection of Staphylococcus aureus in Complex Matrices
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01324K, Paper
Rui Zhao, Qishuo Wang, Yunqing Wang, Rongchao Mei, Xiaoyan Wang, Lingxin Chen
Rapid detection of bacteria in complex matrices remains challenging due to substantial interference in signal readout. This study developed a novel near-infrared (NIR) surface-enhanced Raman scattering (SERS) sensor featuring exceptional...
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3D-printed hollow microneedle-based electrochemical sensor for wireless glucose monitoring

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01058F, Paper
Chuchu Chen, Yonghao Fu, Yuehe Lin, Yun Liu, Dan Du, Kaiyan Qiu
A wearable electrochemical sensor combining a 3D-printed hollow microneedle array, a finger-activated pump, and single-atom nanozymes for highly sensitive glucose monitoring.
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Visualization of heated latent fingerprints by synchrotron radiation soft X-ray photoemission electron microscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01158B, Paper
Satoru Hamamoto, Masahisa Takatsu, Hiroyuki Fujiwara, Hideya Okada, Takuo Ohkochi, Shimpei Watanabe, Masaki Oura, Yasuo Seto
Synchrotron radiation soft X-ray photoemission electron microscopy can clearly reveal ridge patterns by specifically and sensitively detecting sodium elements in heated fingerprints, which cannot be visualized by usual observation techniques.
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A Direct Comparison of Antibody and nanoMIP Affinities using Surface Plasmon Resonance and Electrochemical Techniques: A Haemoglobin Model
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01205H, Paper
Open Access Open Access
Subrayal M Reddy, Andrei N Stephen, Barbara V Boldrin
This study presents, for the first time, a direct quantitative comparison between the binding affinities and selectivity of antibodies and their molecularly imprinted polymer (nanoMIP) counterparts for a target protein...
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Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning for lactic acid bacteria identification at strain level

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01093D, Paper
Paul Lagneaux, Nathan Widjaja, Bastien Lagneaux, Thi Kim Chi Nguyen, Hélène Licandro, Pascale Winckler, Yves Waché
Lactic acid bacteria (LAB) are widely used in food, health, and biotechnology sectors. Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning is explored for improved strain level identification.
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The conten...
Flow solitons of supermolecular complex DEAE-dextran-MMA copolymer/small noncoding RNAs for epigenetic change from cancer to normal cells in TME

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00375J, Paper
Oxana V. Klimenko, Rui-Cheng Ji, Masayasu Onishi, Masaaki Mizuno, Naoji Kubota, Yuki Eshita, Yasuhiko Onishi
DDMC (DEAE-dextran-MMA copolymer)/sncRNAs (a-miR-155, piR-30074, and miR-125b) complex completely cured mice with virus-induced sarcoma after cellular reprogramming treatment, transforming cancer cells into normal cells.
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Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01100K, Paper
Open Access Open Access
Sandra Adámez-Rodríguez, María Luisa Marina, María Castro-Puyana
An EKC method using sulfated-γ-cyclodextrin and short-end injection enabled the rapid enantiomeric separation of 5-HTP for dietary supplement quality control.
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The ...
Development of a PCB-based electrochemical aptasensor for Chikungunya virus protein detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01261A, Paper
Syama Sajikumar, Naveenkumar Sureshkumar, V. V. R. Sai, Verma Jyoti, Sujatha Sunil, Ramanathan Srinivasan
Chikungunya E1 protein detection with 10 pM LOD was achieved with a 10 μL sample on a printed circuit board aptasensor. The hexaammine ruthenium redox couple does not attack the Au layer, enables regeneration, and yields reproducible results.
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Recent advances in highly sensitive and specific functional nucleic acid sensors for environmental pollutant detection: from mechanism to application

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01139F, Critical Review
Xue Yang, Huibin Wu, Zhi Zeng, Wen-na Chen, Guang-Xiang Luan, Qiu-long Zhang, Jian-min Chen
Functional nucleic acids (FNAs)—aptamers, RNA-cleaving DNAzymes, G-quadruplex/hemin DNAzymes, gRNAs—are cutting-edge tools for environmental pollutant detection, featuring exceptional stability, specificity, and signal transduction/amplification.
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Pyrrolidone modified magnetic COF materials for the quantitative determination of 25-hydroxyvitamin D in human serum via isotope dilution mass spectrometry

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01098E, Paper
Xiaojie Zhang, Jixing Huang, Yazhou Han, Wentao He, Chuan-fan Ding, Yinghua Yan
A magnetic COF material modified with pyrrolidone and p-aminobenzoic acid was developed for quantifying 25-hydroxyvitamin D from serum via isotope dilution mass spectrometry.
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Systematic evaluation of pre-analytical variables on synovial fluid metabolomic profiles using GC-ToF-MS and UHPLC-MS

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00943J, Paper
Open Access Open Access
Yumna Ladha, Adam Burke, Nigel Gotts, Royston Goodacre, Karina Wright, Jade Perry, Charlotte H Hulme
This work reveals the critical influence of sample preparation methods on synovial fluid metabolome characterisation.
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Correction: Phage-ELISA for ultrasensitive detection of Salmonella enteritidis
Analyst, 2026, Advance Article
DOI: 10.1039/D6AN90004F, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mangmang Shen, Chang Ni, Jiasheng Yuan, Xin Zhou
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Targeted Serum Metabolomics Reveals Alterations in Amino Acid and Neurotransmitter Pathways in Parkinson's Disease
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00961H, Paper
Jiaxin Yang, Dong Wu, Zhiwei Wang, Zhijing Zhang, Xiaowen Zheng, Sheng Wang, Fen Huang, Shuai Song, Qunlin Zhang
Serum metabolomic profiling in Parkinson’s disease (PD) remains underexplored. This study characterized alterations in serum amino acid and neurotransmitter levels in PD using targeted metabolomics and identify associated dysregulated metabolic...
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Reusable Fluorescent Biosensor Based on Morphology-controlled ZIF-8⊃FAM-DNA film
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00017G, Paper
Xiaohu Wang, Dongjun Ren, Yangyi Liu, Yunqing Lu, Jin Wang
As a promising porous material, zeolitic imidazolate framework-8 (ZIF-8) exhibits significant application potential in biosensing. However, its reusability in solution form is limited. In this work, a reusable ZIF-8⊃FAM-DNA film...
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A comprehensive review of C-reactive protein testing methods: from current status to future prospects

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01121C, Tutorial Review
Qian Zhou, Siying Pei, Shuo Yang, Tianwei Liu, Jiayi Wu, Zicheng Xu, Qixu Lu, Haixiao Fang, Qiong Wu
This paper systematically summarises C-reactive protein detection methods, elucidating the core principles and performance optimisation strategies of these techniques, with particular emphasis on emerging non-invasive detection approaches.
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FeS-loaded nitrogen-doped carbon nanozymes for sensitive colorimetric detection of xanthine in urine samples

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01306B, Paper
Xueying Zhu, Shuo Tian, Shuyun Chen, Yunsen Wang, Dianping Tang
A simple and feasible colorimetric sensing platform was designed to detect xanthine in urine samples using FeS-loaded nitrogen-doped carbon nanozymes.
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Evaluation of ToF-SIMS imaging for semi-quantitative mapping of BODIPY-labeled fibronectin surface gradients

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00962F, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chao Liu, Tae Kyong John Kim, Douglas H. Wu, Radhika Atit, Rodrigo A. Somoza, Samuel E. Senyo
A novel semi-quantitative imaging mass spectrometry approach using ToF-SIMS enables high-resolution, sensitive mapping of fibronectin gradients in microfluidic haptotaxis assays beyond the limits of fluorescence microscopy.
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A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models

Analyst, 2026, 151,453-457
DOI: 10.1039/D5AN01169H, Communication
Lifang Guo, Yuxi Ding, Haijiao Wu, Qianxin Long, Zhiyun Zhang, Jianhua Su
A conformation-dependent bifunctional sensor is developed by capitalizing on a vibration-induced emission chromophore for viscosity sensing and an acid-triggered oxazolidine switch for pH sensing.
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Multimodal analytical approaches to nanomaterials: TEM, diffraction, image processing, and fractal analysis

Analyst, 2026, 151,327-355
DOI: 10.1039/D5AN00892A, Tutorial Review
Vadim Volochaev, Arshak A. Tsaturyan
Diverse experimental and computational methods is a productive approach and the most effective route to comprehensive material characterization.
The content of this RSS Feed (c) The Royal Society of Chemistry
Protein-targeted aptamers in liquid biopsy: from efficient screening to precise cancer diagnosis

Analyst, 2026, 151,275-299
DOI: 10.1039/D5AN00864F, Critical Review
Wenjuan Xu, Qingyang Liu, Na Sun, Tian Gao, Renjun Pei
The schematic of early and precise cancer diagnosis based on aptamers selected using SELEX.
The content of this RSS Feed (c) The Royal Society of Chemistry
AQbD-driven UHPLC method for simultaneous quantification of budesonide, glycopyrronium bromide, and salbutamol sulphate: a unified approach for inhalation product and bioanalytical applications

Analyst, 2026, 151,610-622
DOI: 10.1039/D5AN01086A, Paper
Open Access Open Access
Alessio Gaggero, Dalibor Jeremic, Anna Fedorko, Jesús Alberto Afonso Urich
Inhalation therapies often combine budesonide, glycopyrronium bromide, and salbutamol sulphate, necessitating analytical methods capable of their simultaneous quantification.
The content of this RSS Feed (c) The Royal Society of Chemistry
Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy

Analyst, 2026, 151,577-588
DOI: 10.1039/D5AN01114K, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zohreh Mirveis, Nitin Patil, Hugh J. Byrne
Understanding dynamic metabolic processes is central to elucidating cellular function and disease mechanisms.
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From design to application: developments and challenges of nanomaterial-based optical biosensors for Salmonella detection

Analyst, 2026, 151,300-326
DOI: 10.1039/D5AN00910C, Tutorial Review
Bin Wang, Yuan Tian, Zerun Zhang, Tianhan Kai, Jun Xiang, Pian Wu, Ping Ding
This review offers a unified “materials–structure–performance” perspective on nanomaterial-based optical biosensors for rapid Salmonella detection, and summarizes key elements and design principles that enable sensitive and portable sensing.
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Surface charge engineering enhances symmetry and reliability of nanopores formed via dielectric breakdown

Analyst, 2026, 151,597-609
DOI: 10.1039/D5AN00882D, Paper
Guohao Xi, Gang Hu, Jie Ma, Lingzhi Wu, Jing Tu
Variations in the electrical properties of modified layers induce distinct changes in electron cloud distribution.
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Advances and innovations in machine learning-based spectral detection methods for trace organic pollutants

Analyst, 2026, 151,356-388
DOI: 10.1039/D5AN00903K, Tutorial Review
Yiheng Qin, Qiannan Duan, Haoyu Wang, Yonghui Bai, Yihao Qin, Liulu Yao, Fan Song, Mingzhe Wu, Jianchao Lee
The rapid and sensitive detection of trace organic pollutants in water is crucial for ensuring environmental safety.
The content of this RSS Feed (c) The Royal Society of Chemistry
Precise Klebsiella pneumoniae carbapenem resistance prediction by Zn–Cu/MOF-embedded hybrid nanosheet-assisted carbapenemase activity analysis

Analyst, 2026, 151,498-507
DOI: 10.1039/D5AN00967G, Paper
Chenyao Lin, Qiaoping Wu, Menglu Mao, Xuedan Qiu, Chuanfan Ding, Yinghua Yan, Dumei Ma, Qingcao Li
A novel GNP@Zn–Cu/MOF@Au nanocomposite enables rapid and sensitive detection of carbapenemase activity by MALDI-TOF MS, offering a promising tool for clinical antimicrobial resistance testing.
The content of this RSS Feed (c) The Royal Society of Chemistry
Liposome array on a power-free microfluidic device for analysis of nanopore formation

Analyst, 2026, 151,489-497
DOI: 10.1039/D5AN01113B, Paper
Maho Hosokawa, Yiting Zhang, Masaki Ohtawa, Naoki Sasaki
A power-free microchannel-based platform that can accommodate numerous liposomes enables real-time analysis of Amphotericin B-induced nanopore formation, providing a high-throughput tool for screening enhancers and inhibitors of drug activity.
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Smartphone-based fluorescence detection of 2,4-dichlorophenoxyacetic acid using ImageJ analysis on a molecularly imprinted membrane/carbon-dot system via a Schiff-base method

Analyst, 2026, 151,636-649
DOI: 10.1039/D5AN00842E, Paper
Muhammad Sajjad, Wijitar Dungchai, Nisakorn Thongkon
A novel smartphone-assisted fluorescence sensing platform using a molecularly imprinted PVDF/N-CDs composite membrane enables selective and sensitive detection of 2,4-D.
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Identification of organochlorides in distilled fractions of plastic pyrolysis oil using GC × GC coupled with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS) and GC coupled with a halogen selective detector (GC-XSD)

Analyst, 2026, 151,466-477
DOI: 10.1039/D5AN00852B, Paper
Bruno da Costa Magalhães, Pascal Pijcke, Niels Verhoosel, Philip Janssen, Cesare Benedetti, Matthijs Ruitenbeek, Georgios Bellos, Melissa N. Dunkle
A crude plastic pyrolysis oil was distilled into fractions with intervals of 50 °C. By combining different analytical capabilities, several organochlorides were speciated across the distilled fractions.
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Flexible hydrogel sensor based on MoS2 for highly selective dopamine detection against catecholamine cross-interference

Analyst, 2026, 151,542-551
DOI: 10.1039/D5AN01080B, Paper
Jianyu Liu, Xiaolei Gao, Weifang Ma, Liyuan Zhang, Xiaoming Wen, Ming Zhai, Guobi Chai, Wu Fan, Qidong Zhang, Ronghan Wei, Qiyan Wang
Real-time monitoring of dopamine (DA) is vital for understanding neurophysiological processes and diagnosing neurological disorders.
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Single-molecule nanopore profiling of protein domain fragment dynamics and aggregation

Analyst, 2026, 151,478-488
DOI: 10.1039/D5AN01140J, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dapeng Chen, Fei Zheng, Guangle Qin, Chaofan Ma, Wei Liu, Lichun Zou, Haiyan Wang, Jingjie Sha
Single-molecule nanopore profiling reveals voltage- and environment-dependent conformational dynamics, dimerization, and dissociation of SARS-CoV-2 nucleocapsid protein domain fragments, advancing nanopore-based protein domain analysis for antiv...
DNAzyme walker-driven, electrode-surface label/wash-free ultrasensitive ECL miRNA detection via ssDNA-enhanced peroxidase activity of g-C3N4 nanosheets

Analyst, 2026, 151,589-596
DOI: 10.1039/D5AN01164G, Paper
Jingwen Wu, Changgang Pan, Li Wang, Yuefeng Li, Guo-Xi Liang
A DNAzyme walker-driven, label/wash-free ECL biosensor for miRNA detection. The cleavage of substrate strands by the target miRNA releases ssDNA, which dramatically enhances the peroxidase-like activity of g-C3N4, leading to high sensitivity.
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Chemical additives facilitate molecular weight characterization of underivatized dextran by high-resolution electrospray ionization mass spectrometry

Analyst, 2026, 151,516-528
DOI: 10.1039/D5AN01066G, Paper
Yujia Ying, Jiangang Chen, Shaoping Li, Jing Zhao
Ionization is usually difficult for underivatized dextran. After adding chemical additives, large polysaccharide ions can be investigated and their fragments are highly related with the structures.
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Anti-tumour and associated metabolic effects of repurposed afuresertib and taxifolin for glioblastoma treatment

Analyst, 2026, 151,563-576
DOI: 10.1039/D5AN00461F, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rui Chen, Nurcan Gumus, Supisara Jearranaiprepame, Alison Whitby, Ruman Rahman, Dong-Hyun Kim
Treating patient-derived glioblastoma cells with repurposed afuresertib and taxifolin showed strong anti-tumour activities and distinctive metabolic disturbance. Created with BioRender.com.
The content of this RSS Feed (c) The Royal Society of Che...
Advanced multimodal imaging: FLIM, PLIM, and FluoRaman enabled by novel diarylacetylene probes

Analyst, 2026, 151,623-635
DOI: 10.1039/D5AN00953G, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Joshua G. Hughes, Dimitrios Tsikritsis, Alexandra E. Bailie, Camilla Dondi, Eva Dias, Helen H. Fielding, Natalie A. Belsey, Michael Shaw, Stanley W. Botchway, Carrie A. Ambler, John M. Girkin, David R. Chisholm
Integrated fluorescence, lifetime, and Raman imaging of solvatochromic diarylacetylene probes provides complementary insight into...
Progress of lateral flow assays for the detection of molecular and microbial species: from basic formats to microfluids, CRISPR and artificial intelligence

Analyst, 2026, 151,389-452
DOI: 10.1039/D5AN00392J, Tutorial Review
Jamila Husain Kagdi, Vaibhavkumar N. Mehta, Sanjay Jha, Tae Jung Park, Hirakendu Basu, Suresh Kumar Kailasa
Lateral flow assays (LFAs) have recognized as simple analytical approaches for the detection of ionic, molecular and microbial species in biomedical, environmental and agricultural sciences.
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Design and synthesis of fluorescent probes specific for pantetheinase and their application in bioimaging

Analyst, 2026, 151,508-515
DOI: 10.1039/D5AN00338E, Paper
Jiman He, Zhengmin Yang, Cunji Gao, Zhiwei Ouyang, Bingying Cao, Yaling Rao, Liangliang Xiao, Shulin Zhao, Jiangke Qin
The FNJ-PA probe interacts with Vanin-1, it can specifically recognize and cleave the amide bond of the probe, releasing the fluorophore FNJN to recover the fluorescence.
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A label-free approach to simultaneous determination of three endocrine disruptors in river water: angular sweep total fluorescence spectroscopy coupled to multi-way calibration

Analyst, 2026, 151,529-541
DOI: 10.1039/D5AN00925A, Paper
Anupama Vijayan, John Prakash
Three endocrine disruptors, BPA, CBZ and CBR, are detected in river water using a sustainable workflow combining single-step surfactant pretreatment, angular sweep fluorescence spectroscopy, and PLS-based modelling.
The content of this RSS Feed (c) The Royal Society of Chemistry
Pocket-sized lab: rapid screening of Fe(III), Na(I), and pyridoxamine via a smartphone-enabled fluorescent PAD

Analyst, 2026, 151,552-562
DOI: 10.1039/D5AN00968E, Paper
Heni Soni, Krushna Baraiya, Divyesh Chaudhari, Sahaj A. Gandhi, Pinkesh G. Sutariya
A smartphone-assisted fluorescent paper-based analytical device (PAD) for the on-site detection of Fe(III), Na(I), and pyridoxamine vitamin.
The content of this RSS Feed (c) The Royal Society of Chemistry
Hydrazine oxidation on a single electrocatalytic nanoring

Analyst, 2026, 151,458-465
DOI: 10.1039/D5AN00651A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sakshi A. Ailawar, Guillermo Colón-Quintana, Thomas B. Clarke, Jeffrey E. Dick
The schematic illustrates the electrocatalytic oxidation of hydrazine (N2H4) on a gold nanoring electrode deposited on a kinetically inert planar electrode.
The content of this RSS Feed (c) The Royal Society of Chemistry
Reduced drying times enable rapid paper spray analysis of whole blood for clinical toxicology

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01148E, Communication
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Stefania Boccuzzi, David Cowan, Paul I. Dargan, Edward Goucher, Vincenzo Abbate
Drying whole blood spots for 10 minutes rather than 60 minutes gave equivalent performance by paper spray ionisation–mass spectrometry, preserving identification and quantitation, and enablingconfirmatory toxicology results within 15 minutes.
To c...
Recent advances in Golgi-targeted fluorescent probes in ferroptosis research

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01240F, Critical Review
Shuai Wang, Wei Guo, Bo-Wen Wan, Kai-Ming Wang, Baoli Dong, Cheng-Shi Jiang, Juan Zhang
Ferroptosis, an iron-dependent modality of regulated cell death mediated by lipid peroxidation, has emerged as a central regulator of diverse pathologies, including tumorigenesis and neurodegeneration.
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AminoacidDB: a liquid chromatography-tandem mass spectrometry-based toolkit for the untargeted analysis of non-protein amino acids

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01248A, Paper
Open Access Open Access
Pawanjit K. Sandhu, Ryland T. Giebelhaus, Ryan Hayward, Tingting Zhao, Alix Tucker, Daniel Gaudet, Tao Huan, Susan J. Murch
Non-protein amino acids (npAAs) are metabolites with amine (NH2) and carboxyl (COOH) moieties. Their natural diversity is not well understood. We created an analytical toolkit including SOPs, statis...
SPEC 2024: International Conference on Clinical Spectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90089A, Editorial
Martha Vardaki, Nikolaos Kourkoumelis
Martha Vardaki and Nikolaos Kourkoumelis introduce the Analyst themed collection on the SPEC24: International Conference on Clinical Spectroscopy.
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Microchip electrophoretic sensing of multiplex microRNAs based on dual nucleic acid amplification

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00625B, Paper
Qihui Xie, Shuang Tang, Jianan Lv, Xing Geng, Fan Zhang, Qingjiang Wang
A multiplex microRNA detection method based on microchip electrophoresis was developed to achieve high sensitivity and specificity.
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A synergistic bimetallic MOF/MWCNT nanocomposite for sensitive electrochemical detection of baicalin
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01276G, Paper
Yijie Zhang, Yongxin Tao, Shan Li, Yong Qin, Jinmin Wang
Baicalin (Bn), a bioactive compound derived from natural plants, has significant pharmaceutical value and is used in the treatment of diseases such as influenza. However, excessive baicalin administration may lead...
The content of this RSS Feed (c) The Royal Society of Chemistry
Synchronous dual-mode sensing platform based on 1D chiral ionic COF for epoxiconazole detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01101A, Paper
Yeqian Ruan, Xiaodong Zheng, Xuan Kuang, Shusheng Li
Pesticide misuse leads to environmental contamination and food safety risks.
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Cobalt nanoparticle-encapsulated N-doped carbon nanotubes on 3D porous carbon: a novel platform for ultrasensitive electrochemical sensing of rutin

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01027F, Paper
Zhewei Zhang, Zijian Zhao, Yaqi Yang
This work develops an ultrasensitive electrochemical sensor for detecting rutin (Rt) using a composite material, Co@N-CNTs/3DHC.
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An "off-on" Electrochemiluminescence Biosensor Based on CRISPR-Cas12a for Ultrasensitive Determination of Aflatoxin B1
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01369K, Paper
Zhi-Hong Xu, Xiao Hu, Xin Weng, Ruo-Mei Lin, wen Xu, Lishuang Yu, Hang Gao
Accurate and sensitive determination of aflatoxin B1 (AFB1) is of vital importance for food safety. Herein, an electrochemiluminescence (ECL) " off-on " switch sensor combined with CRISPR-Cas12a is fabricated for...
The content of this RSS Feed (c) The Royal Society of Chemistry
Conductive polymer-based electrochemical aptasensor for sensitive detection of cylindrospermopsin in water resources

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01285F, Paper
Ece Kesici-Meco, Ece Unur-Yilmaz
Conductive polymer-based electrochemical aptasensors enable rapid, sensitive, and selective detection of cylindrospermopsin in water.
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Construction of hollow double shell NiMn PBA nanozymes for sensitive sarcosine detection via a cascade strategy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01252J, Paper
Yiwen Sun, Ying Xie, Zixuan Yuan, Yujiao Mao, Huiru Liu, Yiting Zhu, Jinyu Dong, Xiaojun Chen
A novel NiMn-PBA-DSNB nanozyme was designed to realize sensitive sarcosine detection via an “enzyme–nanozyme” cascade reaction.
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Diffusion kinetics of volatile organic compounds monitored by nanohole surface plasmonics

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01181G, Paper
Open Access Open Access
Swapnil Daxini, Chris Prüfert, Paul Reid, Pedro Barros, Juan Gomez-Cruz, Carlos Escobedo, Jack A. Barnes, Hans-Peter Loock
The extraordinary optical transmission, EOT, through a gold-film nanohole array was used to measure refractive index changes of a thin film of polydimethylsiloxane, PDMS, upon absorption of o-xylene...
Gas-phase esterification within a miniature ion trap mass spectrometer: mechanistic insight and diagnostic markers for quinolone screening

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01210D, Paper
Wei Wang, Baokun Yang, Jie Hong, Xinhui Yu, Baoqiang Li, Wei Xu, Yanbing Zhai
A gas-phase SN2 esterification reaction between quinolone and alcohol molecules is occurred in a linear ion trap during collision-induced dissociation, where generated adduct ions could be used as diagnostic markers for quinolone screening.
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A photonic crystal sensing array based on a tandem CRISPR/Cas13a system for ultra-sensitive and high-throughput detection of the CVA6 virus

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01178G, Paper
Linyao Wang, Liqian Su, Wanjiang Gu, Shujun Nie, Jie Luo, Yongru Li, Ao Pan, Yongxin Li
A tandem CRISPR/Cas13a system coupled with a photonic crystal array enables ultra-sensitive, high-throughput detection of CVA6.
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Research on a spatiotemporal prediction method for two-dimensional temperature fields based on TDLAS array sensors and the SwinLSTM model

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01304F, Paper
Yongxin Hou, Rui Jia, Shenxiang Feng, Yanlin Wu, Pan Pei, Junjie Ma, Biming Mo, Hongkai Wei, Xiaojian Hao
Use of an array sensor to obtain complete two-dimensional spatial information of a flame, combined with a SwinLSTM model for spatiotemporal prediction.
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Exploiting Pfu DNA polymerase's differential bypass capacity for AP vs. dU sites: a novel strategy for sensitive uracil-DNA glycosylase detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01082A, Paper
Run-Hong Zhang, Chen-Yu Xue, Jia-Hui Dong, Xu-Yang Shen, Yi-Xuan Gu, Ying Liu, Ying-Lin Zhou, Xin-Xiang Zhang
A novel UDG assay exploiting the differential bypass capacity of Pfu DNA polymerase for AP sites over dU sites enables sensitive detection.
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Recent advances and applications of capillary electrophoresis-sodium dodecyl sulfate for characterization and fragment identification of monoclonal antibodies and their derivatives

Analyst, 2026, 151,93-104
DOI: 10.1039/D5AN00918A, Minireview
Open Access Open Access
Yalan Yang, Meng Li, Gangling Xu, Yongbo Ni, Luyun Guo, Chuanfei Yu
The applications of CE-SDS in analyzing the purity and fragments of mAbs, characterizing positional isomers of ADCs, and identifying mismatch impurities in bsAbs and details key regulatory considerations for CE-SDS in biopharmaceutical development.
The co...
Precision silver carp allergy profiling and rapid IgE epitope mapping by a microfluidic chip-MALDI-TOF MS system and prediction models

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01161B, Paper
Winnie C. Soko, Chunqian Zuo, Ruirui Xu, Fang Lin, Qin Qin, Jing Xie, Hongyan Bi
Food allergies are increasing at an alarming rate, and it has become necessary to identify patient-specific allergens for personalized allergy immunotherapy treatments.
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A cascaded catalytic hairpin 3D DNA walker-assisted dual-targeting biomimetic sensor for intracellular microRNA imaging

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01152C, Paper
Lanlan Jia, Jialin Guo, Min Li, Tingting Zhang, Yihan Sun, Yuxin Chen, Xiaoyu Xie, Qi Hu
Schematic representation of a dual-targeting biomimetic sensor for intracellular miRNA-21 imaging.
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Correction: Highly-selective and sensitive plasmon-enhanced fluorescence sensor of aflatoxins
Analyst, 2026, 151,261-261
DOI: 10.1039/D5AN90087E, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tetyana Sergeyeva, Daria Yarynka, Vitaly Lytvyn, Petro Demydov, Andriy Lopatynskyi, Yevgeny Stepanenko, Oleksandr Brovko, Anatoliy Pinchuk, Volodymyr Chegel
The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: High-sensitivity SpectroChip-integrated LFIA platform for rapid point-of-care quantification of cardiovascular biomarkers
Analyst, 2026, 151,260-260
DOI: 10.1039/D5AN90088C, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Cheng-Hao Ko, Wei-Yi Kong
The content of this RSS Feed (c) The Royal Society of Chemistry
Vibrational spectroscopy combined with chemometric approaches in bacterial studies: a review of recent advances and applications

Analyst, 2026, 151,39-62
DOI: 10.1039/D5AN00802F, Tutorial Review
Maryam Kazemi, Arash Mahboubi, Reza Jahani, Hamid Reza Moghimi
Vibrational spectroscopy combined with chemometrics is expected to provide a high-throughput and a more efficient analytical approach for handling bacterial infections as one of the leading causes of global mortality and public health challenges.
The content of this RSS Feed (c) The Royal Society of Chemistry
A reagent-centred thermal control system driven by a cascade temperature control algorithm for high-speed PCR

Analyst, 2026, 151,237-250
DOI: 10.1039/D5AN00965K, Paper
Yuheng Luo, Wangyang Hu, Jiajia Wu, Baoce Sun, Gang Jin, Qiang Xu
Accelerating quantitative polymerase chain reaction (qPCR) without compromising analytical fidelity remains a significant challenge in molecular diagnostics, primarily due to the thermal lag between heating elements and reagents.
The content of this RSS Feed (c) The Royal Society of Chemistry
Development of liquid biopsy for screening colorectal cancer through the combination of an antibody microarray-based metal-enhanced sandwich immunofluorescent assay of cytokines with machine learning

Analyst, 2026, 151,150-156
DOI: 10.1039/D5AN01041A, Paper
Wanyu Zhang, Shasha Li, Xudong Sun, Zhenxin Wang
The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC).
The content of this RSS Feed (c) The Royal Society of Chemistry
A practical guide to working with nanopipettes

Analyst, 2026, 151,11-20
DOI: 10.1039/D5AN01128K, Tutorial Review
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dominik Duleba, Adria Martínez-Aviñó, Robert P. Johnson
This perspective provides a practical guide to nanopipette fabrication, filling, surface modification, and characterisation. Various tips are given to facilitate more efficient workflows and increase research quality and throughput.
The content of this RSS Feed (c) The Roya...
A valence-state-defect–mediated copper nanocluster nanozyme with high peroxidase-like activity for multimodal colorimetric detection of mercury(II)

Analyst, 2026, 151,105-110
DOI: 10.1039/D5AN01159K, Communication
Zhong-Xia Wang, Peng Shan, Ze-Yu Sun, Weijie Ding, Fen-Ying Kong, Heng-Ye Li, Wei Wang
CuNC-based nanozyme multimodal colorimetric mercury(II) sensing is reported for the first time, demonstrating portability, manipulation, and rapid, selective and sensitive signal response.
The content of this RSS Feed (c) The Royal Society of Chemistry
Electrochemical determination of copper in seawater based on a patch-type integrated electrode modified with gold nanoparticle-decorated carbon nanoflowers

Analyst, 2026, 151,219-225
DOI: 10.1039/D5AN01083G, Paper
Shengjie Chu, Fei Pan, Yuxuan Zhang, Haitao Han, Dawei Pan, Xueping Hu
A patch-type integrated electrochemical sensor based on carbon nanoflowers/gold nanoparticles for determination of copper in seawater.
The content of this RSS Feed (c) The Royal Society of Chemistry
Integrated microfluidic platform for programmable multi-window DNA fractionation and in situ recovery

Analyst, 2026, 151,164-173
DOI: 10.1039/D5AN01091H, Paper
Dongliang Li, Chunlei Yang, Leiyang Xu, Tao Zeng, Xiao Shi, Quanxin Yun, Yuliang Dong, Yuning Zhang
An on-chip MFIGE platform integrating programmable DNA size selection with in situ dual-membrane recovery, enabling multi-window, high-fidelity enrichment of long fragments in a closed, low-shear, automation-ready format for long-read sequencing.
The content of this RSS Feed (c) The Royal Society of Chemistry
H2O2-free colorimetric sensing platform of Mn-doped carbon dots with oxidase-mimetic activity for the detection of glutathione in liver disease serum

Analyst, 2026, 151,121-129
DOI: 10.1039/D5AN00964B, Paper
Lin Bo, Lili Jiang, Zhaogui Deng, Minmin Xu, Yifei Liu, Hui Zhang, Xianwei Zuo, Haitao Yu
Schematic of the functional principle of the colorimetric detection of GSH with the oxidase-like mimetic activity of Mn-CDs.
The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy
Analyst, 2026, 151,259-259
DOI: 10.1039/D5AN90081F, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
R. González-Vegas, O. Seksek, A. Bertho, J. Bergs, R. Hirayama, T. Inaniwa, N. Matsufuji, T. Shimokawa, Y. Prezado, I. Yousef, I. Martínez-Rovira
The content of this RSS Feed (c) The Royal Society of Chemistry
Protection-free fabrication of glycopolymer-decorated electrodes for label-free electrochemical detection of pathogenic bacteria

Analyst, 2026, 151,116-120
DOI: 10.1039/D5AN01136A, Communication
Lucen Li, Qinhan Chen, Aobin Han, Qiaolin Guo, Minghui Wang, Wei Song, Jing Lin, Gefei Li
A protection-free interfacial glycosylation strategy was developed to fabricate glycopolymer-modified electrodes, enabling label-free detection of pathogenic bacteria down to 102 CFU mL−1 in real food samples.
The content of this RSS Feed (c) The Royal Society of Chemistry
Advances in gene-targeted diagnostics for pathogenic Escherichia coli

Analyst, 2026, 151,63-92
DOI: 10.1039/D5AN00836K, Tutorial Review
Linlin Zhuang, Jiansen Gong, Mengling Zhu, Ying Zhao, Xue Lian, Chuang Zhou, Xia Cao, Yu Zhang, Qiuping Shen
This review provides a comprehensive overview of gene-targeted diagnostics for pathogenic Escherichia coli, covering nucleic acid hybridization, PCR-based methods, isothermal amplification, biosensors, sequencing technologies, and emerging assays.
The content of this RSS Feed (c) The Royal Society of Chemistry
A fast-responding dual-mode probe for colorimetric and turn-on fluorescence sensing of mercury(II) in water and living cells

Analyst, 2026, 151,111-115
DOI: 10.1039/D5AN00908A, Communication
Yanxin Wu, Huiyuan Wang, Kai Wei, Chendong Ji, Meizhen Yin
A mercury-sensitive probe (Cy-M) exhibits high sensitivity, excellent selectivity, and low detection limits with rapid response times. Its dual-mode sensing enables naked-eye detection of Hg2+ and live-cell imaging via turn-on fluorescence.
The content of this RSS Feed (c) The Royal Society of Chemistry
A fluorescence biosensor based on a cell-free transcription system for species-specific DNA sequence detection and seahorse product identification

Analyst, 2026, 151,157-163
DOI: 10.1039/D5AN01099C, Paper
Linyue Tang, Qian Xie, Ming Chen, Cuiying Lin, Fang Luo, Zhongqin Li, Zhenyu Lin
A fluorescent biosensor based on a cell-free RNA transcription system was developed for species-specific DNA sequence detection and seahorse product identification.
The content of this RSS Feed (c) The Royal Society of Chemistry
Characterizing DPPM inhibition of butyrylcholinesterase: integrated enzymatic kinetics and Raman spectroscopy with chemometric analysis

Analyst, 2026, 151,206-218
DOI: 10.1039/D5AN01018G, Paper
Aubrey Barney, Ashley Newland, Abraham Olayeri, Jan Halámek, Lenka Halámková
Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry
Computational and design of experiment strategies to improve differentiation and quantitation of trace-level cannabinoids by copper cationization paper spray mass spectrometry

Analyst, 2026, 151,226-236
DOI: 10.1039/D5AN01073J, Paper
Open Access Open Access
Jindar N. S. Sboto, Chris G. Gill
Copper cationization with paper spray mass spectrometry is sensitive and specific for quantifying cannabinoids. Design of experiment and density functional theory provided optimal metal ion candidates and paper substrate preparation conditions.
The content of this RSS Feed (c) The Royal Socie...
Dramatically enhancing electrochemiluminescence performance in the aqueous phase using naphthalene diimides with excellent electron-transfer capability and water solubility

Analyst, 2026, 151,251-258
DOI: 10.1039/D5AN01074H, Paper
Dalong Xu, Yuqi Wang, Mingxiu Tian, Liuxiang Chen, Zhengang Han
Luminescent substances with superior electron transfer capability and excellent water solubility are ideal candidates for constructing high-performance electrochemiluminescence (ECL) sensors.
The content of this RSS Feed (c) The Royal Society of Chemistry
Microanalysis of a single droplet produced by optical tweezers in an aqueous solution of bovine serum albumin

Analyst, 2026, 151,130-136
DOI: 10.1039/D5AN01045D, Paper
Ayana Takayanagi, Yasuyuki Tsuboi, Ken-ichi Yuyama
We apply optical tweezers to form a single protein-rich microdroplet in a BSA–YCl3 solution, enabling precise in situ microscopic and microspectroscopic analyses through high spatial and temporal control of liquid–liquid phase separation.
The content of this RSS Feed (c) The Royal Society of Chemistry
Boosting living Bacillus spore identification: Kolmogorov–Arnold network-guided convolutional neural network combined with laser tweezers Raman spectroscopy

Analyst, 2026, 151,187-197
DOI: 10.1039/D5AN00834D, Paper
Yifan Sun, Xiao Peng, Fusheng Du, Lin He, Yuan Lu, Yufeng Yuan, Junle Qu
As primary carriers of foodborne and zoonotic diseases, Bacillus spores can pose a serious threat to food microbiology and human disease.
The content of this RSS Feed (c) The Royal Society of Chemistry
Transition metal doping boosting paper-based photoelectrochemical immunosensing for neurofilament light chain protein detection

Analyst, 2026, 151,180-186
DOI: 10.1039/D5AN01030F, Paper
Cheng-Hua Xu, An-Yang Tao, Mei-Qing Meng, Xi-Le Zhang, Cheng Fang, Feng-Zao Chen, De-Man Han
Early diagnosis of neurodegenerative diseases relies on highly sensitive detection of their specific biomarkers.
The content of this RSS Feed (c) The Royal Society of Chemistry
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