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- Reduced drying times enable rapid paper spray analysis of whole blood for clinical toxicology
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01148E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stefania Boccuzzi, David Cowan, Paul I. Dargan, Edward Goucher, Vincenzo Abbate
Drying whole blood spots for 10 minutes rather than 60 minutes gave equivalent performance by paper spray ionisation–mass spectrometry, preserving identification and quantitation, and enablingconfirmatory toxicology results within 15 minutes.
To c... - Recent advances in Golgi-targeted fluorescent probes in ferroptosis research
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01240F, Critical ReviewShuai Wang, Wei Guo, Bo-Wen Wan, Kai-Ming Wang, Baoli Dong, Cheng-Shi Jiang, Juan Zhang
Ferroptosis, an iron-dependent modality of regulated cell death mediated by lipid peroxidation, has emerged as a central regulator of diverse pathologies, including tumorigenesis and neurodegeneration.
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The content of this RSS Feed (c) The Royal Societ... - AminoacidDB: a liquid chromatography-tandem mass spectrometry-based toolkit for the untargeted analysis of non-protein amino acids
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01248A, Paper Open Access
  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pawanjit K. Sandhu, Ryland T. Giebelhaus, Ryan Hayward, Tingting Zhao, Alix Tucker, Daniel Gaudet, Tao Huan, Susan J. Murch
Non-protein amino acids (npAAs) are metabolites with amine (NH2) and carboxyl (COOH) moieties. Their natural diversity is not well understood. We created an analytical toolkit including SOPs, statis... - SPEC 2024: International Conference on Clinical Spectroscopy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90089A, EditorialMartha Vardaki, Nikolaos Kourkoumelis
Martha Vardaki and Nikolaos Kourkoumelis introduce the Analyst themed collection on the SPEC24: International Conference on Clinical Spectroscopy.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Microchip electrophoretic sensing of multiplex microRNAs based on dual nucleic acid amplification
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00625B, PaperQihui Xie, Shuang Tang, Jianan Lv, Xing Geng, Fan Zhang, Qingjiang Wang
A multiplex microRNA detection method based on microchip electrophoresis was developed to achieve high sensitivity and specificity.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A synergistic bimetallic MOF/MWCNT nanocomposite for sensitive electrochemical detection of baicalin
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01276G, PaperYijie Zhang, Yongxin Tao, Shan Li, Yong Qin, Jinmin Wang
Baicalin (Bn), a bioactive compound derived from natural plants, has significant pharmaceutical value and is used in the treatment of diseases such as influenza. However, excessive baicalin administration may lead...
The content of this RSS Feed (c) The Royal Society of Chemistry - Synchronous dual-mode sensing platform based on 1D chiral ionic COF for epoxiconazole detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01101A, PaperYeqian Ruan, Xiaodong Zheng, Xuan Kuang, Shusheng Li
Pesticide misuse leads to environmental contamination and food safety risks.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Cobalt nanoparticle-encapsulated N-doped carbon nanotubes on 3D porous carbon: a novel platform for ultrasensitive electrochemical sensing of rutin
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01027F, PaperZhewei Zhang, Zijian Zhao, Yaqi Yang
This work develops an ultrasensitive electrochemical sensor for detecting rutin (Rt) using a composite material, Co@N-CNTs/3DHC.
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The content of this RSS Feed (c) The Royal Society of Chemistry - An "off-on" Electrochemiluminescence Biosensor Based on CRISPR-Cas12a for Ultrasensitive Determination of Aflatoxin B1
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01369K, PaperZhi-Hong Xu, Xiao Hu, Xin Weng, Ruo-Mei Lin, wen Xu, Lishuang Yu, Hang Gao
Accurate and sensitive determination of aflatoxin B1 (AFB1) is of vital importance for food safety. Herein, an electrochemiluminescence (ECL) " off-on " switch sensor combined with CRISPR-Cas12a is fabricated for...
The content of this RSS Feed (c) The Royal Society of Chemistry - Conductive polymer-based electrochemical aptasensor for sensitive detection of cylindrospermopsin in water resources
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01285F, PaperEce Kesici-Meco, Ece Unur-Yilmaz
Conductive polymer-based electrochemical aptasensors enable rapid, sensitive, and selective detection of cylindrospermopsin in water.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Construction of hollow double shell NiMn PBA nanozymes for sensitive sarcosine detection via a cascade strategy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01252J, PaperYiwen Sun, Ying Xie, Zixuan Yuan, Yujiao Mao, Huiru Liu, Yiting Zhu, Jinyu Dong, Xiaojun Chen
A novel NiMn-PBA-DSNB nanozyme was designed to realize sensitive sarcosine detection via an “enzyme–nanozyme” cascade reaction.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Temporal SERS Quantification, Chemometric Monitoring of Amikacin Release in Blood Serum from Stimuli-Responsive Drug Carrier: Kinetics Modeling and In-Vitro Pharmacodynamic Evaluation
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01153A, PaperAnfal Fatima, Nasir Mehmood, Ali Akbar, Abdul Naman, Mohammed Alissa , Ghadah S. Abusalim , Adil Abalkhail , Minseok Kim
The controlled delivery of antibiotics from stimuli-responsive hydrogel is a promising approach, although controlled release kinetics and pharmacodynamic (PD) outcomes are very challenging to measure accurately. In this research work,...
The content of this RSS Feed (c) The Royal Society of Chemistry - A Comprehensive Review of C-Reactive Protein Testing Methods: From Current Status to Future Prospects
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01121C, Tutorial ReviewQian Zhou, Siying Pei, Shou Yang, Tianwei Liu, Jiayi Wu, Zicheng Xu, Qixu Lu, Haixiao Fang, Qiong Wu
C-reactive protein (CRP) is a sensitive inflammatory biomarker primarily synthesised by the liver. When the body is infected, inflamed, or tissue is damaged, the CRP content in the body will...
The content of this RSS Feed (c) The Royal Society of Chemistry - Diffusion kinetics of volatile organic compounds monitored by nanohole surface plasmonics
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01181G, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Swapnil Daxini, Chris Prüfert, Paul Reid, Pedro Barros, Juan Gomez-Cruz, Carlos Escobedo, Jack A. Barnes, Hans-Peter Loock
The extraordinary optical transmission, EOT, through a gold-film nanohole array was used to measure refractive index changes of a thin film of polydimethylsiloxane, PDMS, upon absorption of o-xylene... - Gas-phase esterification within a miniature ion trap mass spectrometer: mechanistic insight and diagnostic markers for quinolone screening
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01210D, PaperWei Wang, Baokun Yang, Jie Hong, Xinhui Yu, Baoqiang Li, Wei Xu, Yanbing Zhai
A gas-phase SN2 esterification reaction between quinolone and alcohol molecules is occurred in a linear ion trap during collision-induced dissociation, where generated adduct ions could be used as diagnostic markers for quinolone screening.
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The content of this RSS Feed (... - A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01169H, CommunicationLifang Guo, Yuxi Ding, Haijiao Wu, Qianxin Long, Zhiyun Zhang, Jianhua Su
A conformation-dependent bifunctional sensor is developed by capitalizing on a vibration-induced emission chromophore for viscosity sensing and an acid-triggered oxazolidine switch for pH sensing.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A photonic crystal sensing array based on a tandem CRISPR/Cas13a system for ultra-sensitive and high-throughput detection of the CVA6 virus
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01178G, PaperLinyao Wang, Liqian Su, Wanjiang Gu, Shujun Nie, Jie Luo, Yongru Li, Ao Pan, Yongxin Li
A tandem CRISPR/Cas13a system coupled with a photonic crystal array enables ultra-sensitive, high-throughput detection of CVA6.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Research on a spatiotemporal prediction method for two-dimensional temperature fields based on TDLAS array sensors and the SwinLSTM model
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01304F, PaperYongxin Hou, Rui Jia, Shenxiang Feng, Yanlin Wu, Pan Pei, Junjie Ma, Biming Mo, Hongkai Wei, Xiaojian Hao
Use of an array sensor to obtain complete two-dimensional spatial information of a flame, combined with a SwinLSTM model for spatiotemporal prediction.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Electrochemical immunosensor based on MXene-Au and Au-Ce-COF to detect methyl parathion
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01289A, PaperPeiyao Zhu, Deyu Liu, Yaqi Chen, Haiping Huang, Fang Xu
A novel electrochemical immunosensor based on MXene-Au and Au-Ce-COF was constructed and applied for the ultrasensitive detection of methyl parathion (PTM). The MXene-Au nanomaterials were obtained by acid etching the...
The content of this RSS Feed (c) The Royal Society of Chemistry - Exploiting Pfu DNA polymerase's differential bypass capacity for AP vs. dU sites: a novel strategy for sensitive uracil-DNA glycosylase detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01082A, PaperRun-Hong Zhang, Chen-Yu Xue, Jia-Hui Dong, Xu-Yang Shen, Yi-Xuan Gu, Ying Liu, Ying-Lin Zhou, Xin-Xiang Zhang
A novel UDG assay exploiting the differential bypass capacity of Pfu DNA polymerase for AP sites over dU sites enables sensitive detection.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Development of a PCB–based Electrochemical Aptasensor for Chikungunya Virus Protein Detection
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01261A, PaperSyama Sajikumar, Naveenkumar Sureshkumar, V. V. R. Sai, Verma Jyoti, Sujatha Sunil, Ramanathan Srinivasan
Chikungunya is a mosquito–borne viral infection, and its accurate identification is critical to avoid misdiagnosis. Herein, we demonstrate the development of a cost–effective, printed circuit board (PCB) –based biosensor platform...
The content of this RSS Feed (c) The Royal Society of Chemistry - Recent advances and applications of capillary electrophoresis-sodium dodecyl sulfate for characterization and fragment identification of monoclonal antibodies and their derivatives
- Analyst, 2026, 151,93-104
DOI: 10.1039/D5AN00918A, Minireview Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yalan Yang, Meng Li, Gangling Xu, Yongbo Ni, Luyun Guo, Chuanfei Yu
The applications of CE-SDS in analyzing the purity and fragments of mAbs, characterizing positional isomers of ADCs, and identifying mismatch impurities in bsAbs and details key regulatory considerations for CE-SDS in biopharmaceutical development.
The co... - Precision silver carp allergy profiling and rapid IgE epitope mapping by a microfluidic chip-MALDI-TOF MS system and prediction models
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01161B, PaperWinnie C. Soko, Chunqian Zuo, Ruirui Xu, Fang Lin, Qin Qin, Jing Xie, Hongyan Bi
Food allergies are increasing at an alarming rate, and it has become necessary to identify patient-specific allergens for personalized allergy immunotherapy treatments.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Protein-targeted aptamers in liquid biopsy: from efficient screening to precise cancer diagnosis
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00864F, Critical ReviewWenjuan Xu, Qingyang Liu, Na Sun, Tian Gao, Renjun Pei
The schematic of early and precise cancer diagnosis based on aptamers selected using SELEX.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A cascaded catalytic hairpin 3D DNA walker-assisted dual-targeting biomimetic sensor for intracellular microRNA imaging
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01152C, PaperLanlan Jia, Jialin Guo, Min Li, Tingting Zhang, Yihan Sun, Yuxin Chen, Xiaoyu Xie, Qi Hu
Schematic representation of a dual-targeting biomimetic sensor for intracellular miRNA-21 imaging.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: Highly-selective and sensitive plasmon-enhanced fluorescence sensor of aflatoxins
- Analyst, 2026, 151,261-261
DOI: 10.1039/D5AN90087E, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tetyana Sergeyeva, Daria Yarynka, Vitaly Lytvyn, Petro Demydov, Andriy Lopatynskyi, Yevgeny Stepanenko, Oleksandr Brovko, Anatoliy Pinchuk, Volodymyr Chegel
The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: High-sensitivity SpectroChip-integrated LFIA platform for rapid point-of-care quantification of cardiovascular biomarkers
- Analyst, 2026, 151,260-260
DOI: 10.1039/D5AN90088C, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cheng-Hao Ko, Wei-Yi Kong
The content of this RSS Feed (c) The Royal Society of Chemistry - Vibrational spectroscopy combined with chemometric approaches in bacterial studies: a review of recent advances and applications
- Analyst, 2026, 151,39-62
DOI: 10.1039/D5AN00802F, Tutorial ReviewMaryam Kazemi, Arash Mahboubi, Reza Jahani, Hamid Reza Moghimi
Vibrational spectroscopy combined with chemometrics is expected to provide a high-throughput and a more efficient analytical approach for handling bacterial infections as one of the leading causes of global mortality and public health challenges.
The content of this RSS Feed (c) The Royal Society of Chemistry - A reagent-centred thermal control system driven by a cascade temperature control algorithm for high-speed PCR
- Analyst, 2026, 151,237-250
DOI: 10.1039/D5AN00965K, PaperYuheng Luo, Wangyang Hu, Jiajia Wu, Baoce Sun, Gang Jin, Qiang Xu
Accelerating quantitative polymerase chain reaction (qPCR) without compromising analytical fidelity remains a significant challenge in molecular diagnostics, primarily due to the thermal lag between heating elements and reagents.
The content of this RSS Feed (c) The Royal Society of Chemistry - Development of liquid biopsy for screening colorectal cancer through the combination of an antibody microarray-based metal-enhanced sandwich immunofluorescent assay of cytokines with machine learning
- Analyst, 2026, 151,150-156
DOI: 10.1039/D5AN01041A, PaperWanyu Zhang, Shasha Li, Xudong Sun, Zhenxin Wang
The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC).
The content of this RSS Feed (c) The Royal Society of Chemistry - A practical guide to working with nanopipettes
- Analyst, 2026, 151,11-20
DOI: 10.1039/D5AN01128K, Tutorial Review Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dominik Duleba, Adria Martínez-Aviñó, Robert P. Johnson
This perspective provides a practical guide to nanopipette fabrication, filling, surface modification, and characterisation. Various tips are given to facilitate more efficient workflows and increase research quality and throughput.
The content of this RSS Feed (c) The Roya... - A valence-state-defect–mediated copper nanocluster nanozyme with high peroxidase-like activity for multimodal colorimetric detection of mercury(II)
- Analyst, 2026, 151,105-110
DOI: 10.1039/D5AN01159K, CommunicationZhong-Xia Wang, Peng Shan, Ze-Yu Sun, Weijie Ding, Fen-Ying Kong, Heng-Ye Li, Wei Wang
CuNC-based nanozyme multimodal colorimetric mercury(II) sensing is reported for the first time, demonstrating portability, manipulation, and rapid, selective and sensitive signal response.
The content of this RSS Feed (c) The Royal Society of Chemistry - Electrochemical determination of copper in seawater based on a patch-type integrated electrode modified with gold nanoparticle-decorated carbon nanoflowers
- Analyst, 2026, 151,219-225
DOI: 10.1039/D5AN01083G, PaperShengjie Chu, Fei Pan, Yuxuan Zhang, Haitao Han, Dawei Pan, Xueping Hu
A patch-type integrated electrochemical sensor based on carbon nanoflowers/gold nanoparticles for determination of copper in seawater.
The content of this RSS Feed (c) The Royal Society of Chemistry - Integrated microfluidic platform for programmable multi-window DNA fractionation and in situ recovery
- Analyst, 2026, 151,164-173
DOI: 10.1039/D5AN01091H, PaperDongliang Li, Chunlei Yang, Leiyang Xu, Tao Zeng, Xiao Shi, Quanxin Yun, Yuliang Dong, Yuning Zhang
An on-chip MFIGE platform integrating programmable DNA size selection with in situ dual-membrane recovery, enabling multi-window, high-fidelity enrichment of long fragments in a closed, low-shear, automation-ready format for long-read sequencing.
The content of this RSS Feed (c) The Royal Society of Chemistry - H2O2-free colorimetric sensing platform of Mn-doped carbon dots with oxidase-mimetic activity for the detection of glutathione in liver disease serum
- Analyst, 2026, 151,121-129
DOI: 10.1039/D5AN00964B, PaperLin Bo, Lili Jiang, Zhaogui Deng, Minmin Xu, Yifei Liu, Hui Zhang, Xianwei Zuo, Haitao Yu
Schematic of the functional principle of the colorimetric detection of GSH with the oxidase-like mimetic activity of Mn-CDs.
The content of this RSS Feed (c) The Royal Society of Chemistry - Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy
- Analyst, 2026, 151,259-259
DOI: 10.1039/D5AN90081F, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.R. González-Vegas, O. Seksek, A. Bertho, J. Bergs, R. Hirayama, T. Inaniwa, N. Matsufuji, T. Shimokawa, Y. Prezado, I. Yousef, I. Martínez-Rovira
The content of this RSS Feed (c) The Royal Society of Chemistry - Protection-free fabrication of glycopolymer-decorated electrodes for label-free electrochemical detection of pathogenic bacteria
- Analyst, 2026, 151,116-120
DOI: 10.1039/D5AN01136A, CommunicationLucen Li, Qinhan Chen, Aobin Han, Qiaolin Guo, Minghui Wang, Wei Song, Jing Lin, Gefei Li
A protection-free interfacial glycosylation strategy was developed to fabricate glycopolymer-modified electrodes, enabling label-free detection of pathogenic bacteria down to 102 CFU mL−1 in real food samples.
The content of this RSS Feed (c) The Royal Society of Chemistry - Advances in gene-targeted diagnostics for pathogenic Escherichia coli
- Analyst, 2026, 151,63-92
DOI: 10.1039/D5AN00836K, Tutorial ReviewLinlin Zhuang, Jiansen Gong, Mengling Zhu, Ying Zhao, Xue Lian, Chuang Zhou, Xia Cao, Yu Zhang, Qiuping Shen
This review provides a comprehensive overview of gene-targeted diagnostics for pathogenic Escherichia coli, covering nucleic acid hybridization, PCR-based methods, isothermal amplification, biosensors, sequencing technologies, and emerging assays.
The content of this RSS Feed (c) The Royal Society of Chemistry - A fast-responding dual-mode probe for colorimetric and turn-on fluorescence sensing of mercury(II) in water and living cells
- Analyst, 2026, 151,111-115
DOI: 10.1039/D5AN00908A, CommunicationYanxin Wu, Huiyuan Wang, Kai Wei, Chendong Ji, Meizhen Yin
A mercury-sensitive probe (Cy-M) exhibits high sensitivity, excellent selectivity, and low detection limits with rapid response times. Its dual-mode sensing enables naked-eye detection of Hg2+ and live-cell imaging via turn-on fluorescence.
The content of this RSS Feed (c) The Royal Society of Chemistry - A fluorescence biosensor based on a cell-free transcription system for species-specific DNA sequence detection and seahorse product identification
- Analyst, 2026, 151,157-163
DOI: 10.1039/D5AN01099C, PaperLinyue Tang, Qian Xie, Ming Chen, Cuiying Lin, Fang Luo, Zhongqin Li, Zhenyu Lin
A fluorescent biosensor based on a cell-free RNA transcription system was developed for species-specific DNA sequence detection and seahorse product identification.
The content of this RSS Feed (c) The Royal Society of Chemistry - Characterizing DPPM inhibition of butyrylcholinesterase: integrated enzymatic kinetics and Raman spectroscopy with chemometric analysis
- Analyst, 2026, 151,206-218
DOI: 10.1039/D5AN01018G, PaperAubrey Barney, Ashley Newland, Abraham Olayeri, Jan Halámek, Lenka Halámková
Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry - Computational and design of experiment strategies to improve differentiation and quantitation of trace-level cannabinoids by copper cationization paper spray mass spectrometry
- Analyst, 2026, 151,226-236
DOI: 10.1039/D5AN01073J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jindar N. S. Sboto, Chris G. Gill
Copper cationization with paper spray mass spectrometry is sensitive and specific for quantifying cannabinoids. Design of experiment and density functional theory provided optimal metal ion candidates and paper substrate preparation conditions.
The content of this RSS Feed (c) The Royal Socie... - Dramatically enhancing electrochemiluminescence performance in the aqueous phase using naphthalene diimides with excellent electron-transfer capability and water solubility
- Analyst, 2026, 151,251-258
DOI: 10.1039/D5AN01074H, PaperDalong Xu, Yuqi Wang, Mingxiu Tian, Liuxiang Chen, Zhengang Han
Luminescent substances with superior electron transfer capability and excellent water solubility are ideal candidates for constructing high-performance electrochemiluminescence (ECL) sensors.
The content of this RSS Feed (c) The Royal Society of Chemistry - Microanalysis of a single droplet produced by optical tweezers in an aqueous solution of bovine serum albumin
- Analyst, 2026, 151,130-136
DOI: 10.1039/D5AN01045D, PaperAyana Takayanagi, Yasuyuki Tsuboi, Ken-ichi Yuyama
We apply optical tweezers to form a single protein-rich microdroplet in a BSA–YCl3 solution, enabling precise in situ microscopic and microspectroscopic analyses through high spatial and temporal control of liquid–liquid phase separation.
The content of this RSS Feed (c) The Royal Society of Chemistry - Boosting living Bacillus spore identification: Kolmogorov–Arnold network-guided convolutional neural network combined with laser tweezers Raman spectroscopy
- Analyst, 2026, 151,187-197
DOI: 10.1039/D5AN00834D, PaperYifan Sun, Xiao Peng, Fusheng Du, Lin He, Yuan Lu, Yufeng Yuan, Junle Qu
As primary carriers of foodborne and zoonotic diseases, Bacillus spores can pose a serious threat to food microbiology and human disease.
The content of this RSS Feed (c) The Royal Society of Chemistry - Transition metal doping boosting paper-based photoelectrochemical immunosensing for neurofilament light chain protein detection
- Analyst, 2026, 151,180-186
DOI: 10.1039/D5AN01030F, PaperCheng-Hua Xu, An-Yang Tao, Mei-Qing Meng, Xi-Le Zhang, Cheng Fang, Feng-Zao Chen, De-Man Han
Early diagnosis of neurodegenerative diseases relies on highly sensitive detection of their specific biomarkers.
The content of this RSS Feed (c) The Royal Society of Chemistry - Metabolic fingerprinting of periodontal bacteria: a multi-scale mass spectrometry and vibrational spectroscopy approach
- Analyst, 2026, 151,137-149
DOI: 10.1039/D5AN00507H, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jawaher Albahri, Daniel Smaje, Yun Xu, Steven Robinson, Heather Allison, Kathryn A. Whitehead, Howbeer Muhamadali
Periodontitis is a prevalent condition characterised by progressive destruction of the supporting periodontium around teeth, resulting from prolonged interaction between the host immune system and bacterial infection.
The conte... - A DNAzyme amplifier-based immunoassay for small molecule detection
- Analyst, 2026, 151,174-179
DOI: 10.1039/D5AN01013F, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Han Pang, Qiang Zhao
A DNAzyme amplifier-based immunoassay for sensitive detection of small molecules is developed by using DNAzyme labeled small molecules and antibodies coated on microplates.
The content of this RSS Feed (c) The Royal Society of Chemistry - Sensitive detection and accurate bioimaging of circRNA based on sponge amplification using a DNA tetrahedral nanoprobe
- Analyst, 2026, 151,198-205
DOI: 10.1039/D5AN00611B, PaperGege Xie, Shengrong Yu, Rong Feng, Jingwen Chen, Yiming Wang, Haorong Liu, Yong-Xiang Wu, Shengjia Yu, Keqi Tang
Based on the miRNA sponge amplification property of circRNA, a novel fluorescent DNA tetrahedron nanoprobe (DTNP) was developed for highly sensitive detection and in situ bioimaging of circRNA in living cells.
The content of this RSS Feed (c) The Royal Society of Chemistry - Recent advances in fluorescence-colorimetric sensor arrays and their applications in biomedical fields
- Analyst, 2026, 151,21-38
DOI: 10.1039/D5AN00900F, Tutorial ReviewLiuwen Shao, Jiannan Liu, Xinxin Chen, Wenxiang Xiao
Fluorescence colorimetric dual-mode sensor arrays have drawn significant attention in biomedical analysis.
The content of this RSS Feed (c) The Royal Society of Chemistry - Recent Advances in Highly Sensitive and Specific Functional Nucleic Acid Sensors for Environmental Pollutant Detection: From Mechanism to Application
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01139F, Critical ReviewXue Yang, Huibin Wu, Zhi Zeng, Wen-Na Chen, Guangxiang Luan, Qiu-Long Zhang, Jianmin Chen
Functional nucleic acids (FNAs) have emerged as a cutting-edge tool in environmental pollutant detection, attributed to their exceptional stability, robust specificity, and remarkable capacity for signal transduction and amplification. This...
The content of this RSS Feed (c) The Royal Society of Chemistry - Study on Temperature-Responsive Characteristics of Reactant Ions in Corona Discharge Ion Mobility Spectrometry
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01135C, PaperJie Peng, Jingxiong Yu, Changwu Dong, Yihuang Jiang, Hui Xu , Hong-Tao Liu, Yuan Qian, Zejie Fei
Ion mobility spectrometry (IMS) is an analytical technique and can separate gas-phase ions under atmospheric pressure conditions. Using a laboratory-build direct-current positive corona discharge ion mobility spectrometry (CD-IMS), this study...
The content of this RSS Feed (c) The Royal Society of Chemistry - FeS-loaded nitrogen-doped carbon nanozyme for sensitive colorimetric detection of Xanthine in urine samples
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01306B, PaperXueying Zhu, Shuo Tian, Shuyun Chen, Yunsen Wang, Dianping Tang
As a key alkaloid, the concentration of xanthine in the body often reflects various physiological or pathological states of the human body. However, conventional methods for xanthine detection often suffer...
The content of this RSS Feed (c) The Royal Society of Chemistry - Allium macrostemon bunge-like manganese tetroxide composite for sensitive detection of dopamine in human biological samples
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01111F, PaperZhenyu Cheng, Haobin Hu, Ximei Long, Huimin Yue, Zhijun Li, Yun Wu, Xiaoxia Wei, Haiyan Song
A three-dimensional (3D) composite material, which mimics Allium macrostemon bunge-like manganese (Mn) tetroxide (amb-Mn3O4), was prepared utilizing a simple one-pot hydrothermal method.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Third-generation nanopore sequencing: advancing real-time pathogen detection and antimicrobial resistance surveillance in food safety applications
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01028D, Critical ReviewMuhammad Nadeem, Aysha Sarfraz Rizvi, Abdul Rahman, Ghulam Murtaza
Foodborne diseases impact 600 million people annually, causing 420 000 deaths and over $110 billion in economic losses.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Advances and innovations in machine learning-based spectral detection methods for trace organic pollutants
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00903K, Tutorial ReviewYiheng Qin, Qiannan Duan, Haoyu Wang, Yonghui Bai, Yihao Qin, Liulu Yao, Fan Song, Mingzhe Wu, Jianchao Lee
The rapid and sensitive detection of trace organic pollutants in water is crucial for ensuring environmental safety.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Progress of lateral flow assays for the detection of molecular and microbial species: from basic formats to microfluids, CRISPR and artificial intelligence
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00392J, Tutorial ReviewJamila Husain Kagdi, Vaibhavkumar N. Mehta, Sanjay Jha, Tae Jung Park, Hirakendu Basu, Suresh Kumar Kailasa
Lateral flow assays (LFAs) have recognized as simple analytical approaches for the detection of ionic, molecular and microbial species in biomedical, environmental and agricultural sciences.
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The content of this RSS Feed (c) The Roy... - Triggering isothermal exponential amplification of microRNA via liposome fusion
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01087J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mamiko Tsugane, Kosuke Kato, Keisuke Shinohara, Tsutomu Okita, Reiko Sato, Hiroaki Suzuki
Lipid vesicle fusion was used to trigger miRNA-initiated isothermal amplification (EXPAR) inside GUVs. This system enables real-time detection of membrane-encapsulated RNA and offers potential for artificial cells and vesicle-based ... - Creating taxonomically-informed metabolome libraries for any species using the pubchem.bio R package
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00914F, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Corey D. Broeckling
The pubchem.bio R package enables efficient subsetting of PubChem, retaining only biologically associated structures, and further subsetting and scoring via taxonomy to enable the creation of species-specific metabolite libraries.
To cite this article before page numbers are assigned, use the DOI form of citation ab... - A portable smartphone assisted multi-color colorimetric sensor for the detection of mercury ions based on the peroxidase-like activity of platinum nanoparticles
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01167A, PaperShasha Wang, Huiqing Zhang, Li Wang, Chaonan Huang, Jiping Ma, Liyan Wang, Xiaoyan Wang, Lingxin Chen
A portable smartphone-assisted multi-color colorimetric method for Hg2+ detection based on Hg2+-modulated peroxidase-like activity of PtNPs.
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The content of this RSS Feed (c) The Royal Society of Chemistry - On-chip filtration enrichment and ultrasensitive nanozyme-catalyzed colorimetric detection of Streptococcus pneumoniae in saliva samples
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00879D, PaperYuancheng Guo, Zhijie Tu, Hong Chen, Hongjuan Wei, Tianci Wang, Guohui Sun, Zhen Rong
A filter membrane-integrated microfluidic immunosensor for nanozyme-catalyzed detection of S. pneumoniae in clinical samples.
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The content of this RSS Feed (c) The Royal Society of Chemistry - From design to application: developments and challenges of nanomaterial-based optical biosensors for Salmonella detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00910C, Tutorial ReviewBin Wang, Yuan Tian, Zerun Zhang, Tianhan Kai, Jun Xiang, Pian Wu, Ping Ding
This review offers a unified “materials–structure–performance” perspective on nanomaterial-based optical biosensors for rapid Salmonella detection, and summarizes key elements and design principles that enable sensitive and portable sensing.
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The content ... - Multimodal analytical approaches to nanomaterials: TEM, diffraction, image processing, and fractal analysis
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00892A, Tutorial ReviewVadim Volochaev, Arshak A. Tsaturyan
Diverse experimental and computational methods is a productive approach and the most effective route to comprehensive material characterization.
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The content of this RSS Feed (c) The Royal Society of Chemistry - A near-infrared benzothiazole-based fluorescent probe for selective detection of CORM-3 with a large Stokes shift in living cells
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01196E, PaperLiqiang Yan, Junjie Yang, Yanxin Zhang, Ying Sun, Jianmei Zou
This work develops a NIR fluorescent probe for sensitive CORM-3 tracking in living cells and on-site via test strips, offering a robust tool to study CORM-3 biology and therapeutic potential.
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The content of this RSS Feed (c) The Royal Society of Chemistry
