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Megabase-scale human genome rearrangement with programmable bridge recombinases

Science, Ahead of Print.

— Nicholas T. Perry, Liam J. Bartie, Dhruva Katrekar, Gabriel A. Gonzalez, Matthew G. Durrant, James J. Pai, Alison Fanton, Juliana Q. Martins, Masahiro Hiraizumi, Chiara Ricci-Tam, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu 2025-09-25 06:18:42

Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2

Science, Ahead of Print.

— Luke A. Greenhough, Lorenzo Galanti, Chih-Chao Liang, Simon J. Boulton, Stephen C. West 2025-11-06 06:59:18

Different repair pathways support intact or truncated insertions by R2 retrotransposon protein

Science, Ahead of Print.

— Jeremy J. R. McIntyre, Connor A. Horton, Kathleen Collins 2025-11-13 07:00:24

A whole-brain single-cell atlas of circadian neural activity in mice

Science, Ahead of Print.

— Katsunari Yamashita, Fukuaki L. Kinoshita, Shota Y. Yoshida, Katsuhiko Matsumoto, Tomoki T. Mitani, Hiroshi Fujishima, Yoichi Minami, Eiichi Morii, Rikuhiro G. Yamada, Seiji Okada, Hiroki R. Ueda 2025-11-13 07:01:18

Termination of the integrated stress response

Science, Ahead of Print.

— Claudia De Miguel, Sigurdur R. Thorkelsson, Agnieszka Fatalska, George Hodgson, Chao Wang, Anne Bertolotti 2025-11-13 07:00:00

A global screen for magnetically induced neuronal activity in the pigeon brain

Science, Ahead of Print.

— Gregory C. Nordmann, Spencer D. Balay, Thamari N. Kapuruge, Marco Numi, Christoph Leeb, Simon Nimpf, E. Pascal Malkemper, Lukas Landler, David A. Keays 2025-11-20 06:59:04

Synergy between regulatory elements can render cohesin dispensable for distal enhancer function

Science, Ahead of Print.

— Karissa L. Hansen, Annie S. Adachi, Luca Braccioli, Smit Kadvani, Ryan M. Boileau, Moreno Martinovic, Bozhena Pokorny, Rini Shah, Erika C. Anderson, Kaite Zhang, Irié Carel, Kenya Bonitto, Robert Blelloch, Geoffrey Fudenberg, Elzo de Wit, Elphège P. Nora 2025-11-27 07:00:00

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

Science, Ahead of Print.

— Martin S. Taylor, Maggie Chen, Matthew Hancock, Maximilian Wranik, Bryant D. Miller, Timothy R. O’Meara,, Brad A. Palanski, Scott B. Ficarro, Brian J. Groendyke, Yufei Xiang, Kazuma T. Kondo, Karen Y. Linde-Garelli, Michelle J. Lee, Dibyendu Mondal, Daniel Freund, Samantha Congreve, Kaay Matas, Maximiliaan Hennink, Kera Xibinaku, Max L. Valenstein, Trevor van Eeuwen, Jarrod A. Marto, Andrej Sali, Yi Shi, Nathanael S. Gray, David M. Sabatini, Nam Chu, Kacper B. Rogala, Philip A. Cole 2025-11-27 07:00:00

Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration

Science, Ahead of Print.

— Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau, Nidhi Bhutani 2025-11-27 07:00:00

Spatial and morphological organization of mitochondria in neurons across a connectome

Science, Ahead of Print.

— Garrett Sager, Paul Pfeiffer, Heng Wu, Fabian Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colón-Ramos, Susanne Schreiber, Damon A. Clark 2025-12-11 06:59:13

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum

Science, Ahead of Print.

— Alexander M. Scrutton, Nayanika Sengupta, Josip Ivica, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger 2025-12-11 06:59:13

Carbonated ultramafic igneous rocks in Jezero crater, Mars

Science, Ahead of Print.

— Kenneth H. Williford, Kenneth A. Farley, Briony H.N. Horgan, Brad Garczynski, Allan H. Treiman, Sanjeev Gupta, Alexander J. Jones, Sandra Siljeström, Elise Clavé, Lisa Mayhew, Jeffrey T. Osterhout, Eleni Ravanis, Kathryn M. Stack, Sarah Fagents, Candice C. Bedford, Tanja Bosak, Sergei V. Bykov, David Flannery, Kevin P. Hand, Michael W. M. Jones, Linda Kah, Athanasios Klidaras, Justin Maki, Lucia Mandon, Elias Mansbach, Francis M. McCubbin, Justin I. Simon, Anushree Srivastava, Kyle Uckert, ... 2025-12-17 03:31:24

Chromatin buffers torsional stress during transcription

Science, Ahead of Print.

— Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Xiaomeng Jia, Robert M. Fulbright, James T. Inman, Taryn M. Kay, Joshua Jeong, Glenn Hauk, Deanna Gotte, James M. Berger, Mikhail Kashlev, Michelle D. Wang 2025-12-18 07:00:42

Multistep genomics on single cells and live cultures in subnanoliter capsules

Science, Ahead of Print.

— Ignas Mazelis, Haoxiang Sun, Arpita Kulkarni, Theresa L. Torre, Allon M. Klein 2025-12-18 07:00:42

High-throughput single cell omics using semipermeable capsules

Science, Ahead of Print.

— Denis Baronas, Simonas Norvaisis, Justina Zvirblyte, Greta Leonaviciene, Vincenta Mikulenaite, Karolis Goda, Vytautas Kaseta, Karolis Sablauskas, Laimonas Griskevicius, Simonas Juzenas, Linas Mazutis 2025-12-18 07:00:42

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

Science, Ahead of Print.

— Siddhant U. Jain, Kaylyn E. Williamson, Alexander W. Ying, Aasha M. Turner, Ruidong Jerry Jiang, Shaunak Raval, Kevin So, Maxwell J. Allison, Akshay Sankar, Daniel D. Sáme Guerra, Yutong Lin, Zhe Jiang, Nazar Mashtalir, Henry W. Rohrs, Cheryl F. Lichti, Tom W. Muir, Malvina Papanastasiou, Joao A. Paulo, Steven P. Gygi, Michael L. Gross, Cigall Kadoch 2026-01-01 07:00:01

A precessing jet from an active galactic nucleus drives gas outflow from a disk galaxy

Science, Ahead of Print.

— Justin A. Kader, Vivian U, Loreto Barcos-Muñoz, Marina Bianchin, Sean T. Linden, Yiqing Song, Gabriela Canalizo, Archana Aravindan, George C. Privon, Tanio Díaz-Santos, Christopher Hayward, Matthew A. Malkan, Lee Armus, Rosalie C. McGurk, Jeffrey A. Rich, Anne M. Medling, Sabrina Stierwalt, Claire E. Max, Aaron S. Evans, Christopher J. Agostino, Vassilis Charmandaris, Tianmu Gao, Justin H. Howell, Hanae Inami, Thomas S.-Y. Lai, Kirsten L. Larson, Christopher D. Martin, Mateusz Matuszewski, ... 2026-01-08 05:15:00

Computational design of conformation-biasing mutations to alter protein functions

Science, Ahead of Print.

— Peter E. Cavanagh, Andrew G. Xue, Shizhong A. Dai, Albert Qiang, Tsutomu Matsui, Alice Y. Ting 2026-01-08 06:59:00

Mitochondrial control of fuel switching via carnitine biosynthesis

Science, Ahead of Print.

— Christopher Auger, Hiroshi Nishida, Bo Yuan, Guilherme Martins Silva, Masanori Fujimoto, Mark Li, Daisuke Katoh, Dandan Wang, Melia Granath-Panelo, Jihoon Shin, Rose Witte, Jin-Seon Yook, Anthony R. P. Verkerke, Alexander S. Banks, Sheng Hui, Lijun Sun, Shingo Kajimura 2026-01-08 06:59:00

Metallic θ-phase tantalum nitride has a thermal conductivity triple that of copper

Science, Ahead of Print.

— Suixuan Li, Chuanjin Su, Zihao Qin, Ahmet Alatas, Martin Kunz, Takahiro Yamada, Shelly D. Kelly, Mary H. Upton, Anthony Gironda, Jiyong Zhao, Bora Kalkan, Wanli Yang, Toshihiro Aoki, Yongjie Hu 2026-01-15 07:00:05

A genetically encoded device for transcriptome storage in mammalian cells

Science, Ahead of Print.

— Yu-Kai Chao, Michelle Wu, Qiyu Gong, Fei Chen 2026-01-15 07:00:05

Who is using AI to code? Global diffusion and impact of generative AI

Science, Ahead of Print.

— Simone Daniotti, Johannes Wachs, Xiangnan Feng, Frank Neffke 2026-01-22 06:59:00

A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy

Science, Ahead of Print.

— Tian Huang, Charles Hodgens, Sandhan Prakash, Marco Marconi, Krzysztof Wabnik, Rosangela Sozzani, Doris Wagner 2026-01-22 06:59:00

Nutritional specialization and social evolution in woodroaches and termites

Science, Ahead of Print.

— Yingying Cui, Fangfang Liu, Dongwei Yuan, Mingtao Liao, Zhaoxin Li, Yun-Xia Luan, Shuxin Yu, Kesen Zhu, Qian Gao, Yunlong Cheng, Gangqi Fang, Zongqing Wang, Shiming Zhu, Jinlan Xu, Shuai Wang, Melissa Sánchez Herrera, Qiuying Huang, Xiaohong Su, Zhang Wang, Hui Xiang, Nathan Lo, Jacobus J. Boomsma, Shuai Zhan, Sheng Li 2026-01-29 06:59:07

Gigantic piezoelectricity in a polycrystalline ceramic actively maintained at a quadruple point

Science, Ahead of Print.

— Yanshuang Hao, Dipak Kumar Khatua, Dong Wang, Jinghui Gao, Shuai Ren, Yang Yang, Minxia Fang, Dezhen Xue, Jingze Xu, Guanqi Wang, Xiaoqin Ke, Zhizhi Xu, Chang Liu, Qichao Fan, Yuanchao Ji, Le Zhang, Sen Yang, Genshui Wang, Xiaobing Ren 2026-01-29 06:59:07

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy

Science, Ahead of Print.

— Junedh M. Amrute, In-Hyuk Jung, Tracy Yamawaki, Wen-Ling Lin, Andrea Bredemeyer, Johanna Diekmann, Sikander Hayat, Xianglong Zhang, Devin L. Wakefield, Xin Luo, Sidrah Maryam, Gyu Seong Heo, Steven Yang, Chang Jie Mick Lee, Chen Wang, Caroline Chou, Christoph Kuppe, Kevin D. Cook, Atilla Kovacs, Vishnu Chintalgattu, Danielle Pruitt, Jose Barreda, Nathan O. Stitziel, Paul Cheng, Yongjian Liu, Rafael Kramann, Daniel Kreisel, Roger S-Y Foo, Ingrid C. Rulifson, Scott Martin, David Grunert, Meliss... 2026-01-29 06:59:07

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR

Science, Ahead of Print.

— Daniel R Tabet, Atina G Coté, Megan C Lancaster, Jochen Weile, Ashyad Rayhan, Iosifina Fotiadou, Nishka Kishore, Roujia Li, Da Kuang, Jennifer J. Knapp, Carmela Serio Carrero, Olivia Taverniti, Anna Axakova, Jack M.P. Castelli, Mohammad Majharul Islam, Shahin Sowlati-Hashjin, Aanshi Gandhi, Ranim Maaieh, Michael Garton, Kenneth Matreyek, Douglas M Fowler, Mafalda Bourbon, Simon G. Pfisterer, Andrew M. Glazer, Brett M Kroncke, Victoria N. Parikh, Euan A. Ashley, Joshua W. Knowles, Melina Clau... 2025-10-30 05:59:00