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Megabase-scale human genome rearrangement with programmable bridge recombinases

Science, Ahead of Print.

— Nicholas T. Perry, Liam J. Bartie, Dhruva Katrekar, Gabriel A. Gonzalez, Matthew G. Durrant, James J. Pai, Alison Fanton, Juliana Q. Martins, Masahiro Hiraizumi, Chiara Ricci-Tam, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu 2025-09-25 06:18:42

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR

Science, Ahead of Print.

— Daniel R Tabet, Atina G Coté, Megan C Lancaster, Jochen Weile, Ashyad Rayhan, Iosifina Fotiadou, Nishka Kishore, Roujia Li, Da Kuang, Jennifer J. Knapp, Carmela Serio Carrero, Olivia Taverniti, Anna Axakova, Jack M.P. Castelli, Mohammad Majharul Islam, Shahin Sowlati-Hashjin, Aanshi Gandhi, Ranim Maaieh, Michael Garton, Kenneth Matreyek, Douglas M Fowler, Mafalda Bourbon, Simon G. Pfisterer, Andrew M. Glazer, Brett M Kroncke, Victoria N. Parikh, Euan A. Ashley, Joshua W. Knowles, Melina Clau... 2025-10-30 05:59:00

The origin of hepatocellular carcinoma depends on metabolic zonation

Science, Ahead of Print.

— Jason Guo, Roger Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen, Lin Li, Jingjing Wang, Meng-Hsiung Hsieh, Ivy Xiangyi Fang, Benjamin Kroger, Yunguan Wang, Min Zhu, Xiongzhao Ren, Greg Mannino, Yuemeng Jia, Yonglong Wei, Stephen Moore, Daniel J. Siegwart, Stephen S. Chung, Zixi Wang, Tripti Sharma, Suman Komjeti, Yi Han, Purva Gopal, Guanghua Xiao, Tao Wang, Hao Zhu 2025-11-06 06:59:18

Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2

Science, Ahead of Print.

— Luke A. Greenhough, Lorenzo Galanti, Chih-Chao Liang, Simon J. Boulton, Stephen C. West 2025-11-06 06:59:18

Different repair pathways support intact or truncated insertions by R2 retrotransposon protein

Science, Ahead of Print.

— Jeremy J. R. McIntyre, Connor A. Horton, Kathleen Collins 2025-11-13 07:00:24

A whole-brain single-cell atlas of circadian neural activity in mice

Science, Ahead of Print.

— Katsunari Yamashita, Fukuaki L. Kinoshita, Shota Y. Yoshida, Katsuhiko Matsumoto, Tomoki T. Mitani, Hiroshi Fujishima, Yoichi Minami, Eiichi Morii, Rikuhiro G. Yamada, Seiji Okada, Hiroki R. Ueda 2025-11-13 07:01:18

Termination of the integrated stress response

Science, Ahead of Print.

— Claudia De Miguel, Sigurdur R. Thorkelsson, Agnieszka Fatalska, George Hodgson, Chao Wang, Anne Bertolotti 2025-11-13 07:00:00

Pan-family pollen signals control an interspecific stigma barrier across Brassicaceae species

Science, Ahead of Print.

— Yunyun Cao, Xiaoshuang Cui, Yinqing Yang, Lianhui Pan, Fei Yang, Shuyan Li, Dandan Wu, Yuelan Ding, Rui Chen, Nan Wang, Shangjia Liu, Zhaojing Ji, Yuxuan Zhao, Yue Chen, Rui Sun, Shiyu Xian, Lin Yang, Jiyun Hui, Ru Li, Tong Zhang, Shengwei Dou, Gengxing Song, Xiaochun Wei, Yuxiang Yuan, XiaoWei Zhang, Mingming Chen, Xihai Sun, Hen-Ming Wu, Alice Y. Cheung, Qiaohong Duan 2025-11-20 06:59:04

A global screen for magnetically induced neuronal activity in the pigeon brain

Science, Ahead of Print.

— Gregory C. Nordmann, Spencer D. Balay, Thamari N. Kapuruge, Marco Numi, Christoph Leeb, Simon Nimpf, E. Pascal Malkemper, Lukas Landler, David A. Keays 2025-11-20 06:59:04

Synergy between regulatory elements can render cohesin dispensable for distal enhancer function

Science, Ahead of Print.

— Karissa L. Hansen, Annie S. Adachi, Luca Braccioli, Smit Kadvani, Ryan M. Boileau, Moreno Martinovic, Bozhena Pokorny, Rini Shah, Erika C. Anderson, Kaite Zhang, Irié Carel, Kenya Bonitto, Robert Blelloch, Geoffrey Fudenberg, Elzo de Wit, Elphège P. Nora 2025-11-27 07:00:00

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

Science, Ahead of Print.

— Martin S. Taylor, Maggie Chen, Matthew Hancock, Maximilian Wranik, Bryant D. Miller, Timothy R. O’Meara,, Brad A. Palanski, Scott B. Ficarro, Brian J. Groendyke, Yufei Xiang, Kazuma T. Kondo, Karen Y. Linde-Garelli, Michelle J. Lee, Dibyendu Mondal, Daniel Freund, Samantha Congreve, Kaay Matas, Maximiliaan Hennink, Kera Xibinaku, Max L. Valenstein, Trevor van Eeuwen, Jarrod A. Marto, Andrej Sali, Yi Shi, Nathanael S. Gray, David M. Sabatini, Nam Chu, Kacper B. Rogala, Philip A. Cole 2025-11-27 07:00:00

Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration

Science, Ahead of Print.

— Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau, Nidhi Bhutani 2025-11-27 07:00:00

Spatial and morphological organization of mitochondria in neurons across a connectome

Science, Ahead of Print.

— Garrett Sager, Paul Pfeiffer, Heng Wu, Fabian Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colón-Ramos, Susanne Schreiber, Damon A. Clark 2025-12-11 06:59:13

Progressive eastward rupture of the Main Marmara fault toward Istanbul

Science, Ahead of Print.

— Patricia Martínez-Garzón, Xiang Chen, Dirk Becker, Sebastián Núñez-Jara, Recai Feyiz Kartal, Elif Türker, Georg Dresen, Yehuda Ben-Zion, Jorge Jara, Fabrice Cotton, Filiz Tuba Kadirioglu, Tuğbay Kiliç, Marco Bohnhoff 2025-12-11 06:59:13

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum

Science, Ahead of Print.

— Alexander M. Scrutton, Nayanika Sengupta, Josip Ivica, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger 2025-12-11 06:59:13

Carbonated ultramafic igneous rocks in Jezero crater, Mars

Science, Ahead of Print.

— Kenneth H. Williford, Kenneth A. Farley, Briony H.N. Horgan, Brad Garczynski, Allan H. Treiman, Sanjeev Gupta, Alexander J. Jones, Sandra Siljeström, Elise Clavé, Lisa Mayhew, Jeffrey T. Osterhout, Eleni Ravanis, Kathryn M. Stack, Sarah Fagents, Candice C. Bedford, Tanja Bosak, Sergei V. Bykov, David Flannery, Kevin P. Hand, Michael W. M. Jones, Linda Kah, Athanasios Klidaras, Justin Maki, Lucia Mandon, Elias Mansbach, Francis M. McCubbin, Justin I. Simon, Anushree Srivastava, Kyle Uckert, ... 2025-12-17 03:31:24

Chromatin buffers torsional stress during transcription

Science, Ahead of Print.

— Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Xiaomeng Jia, Robert M. Fulbright, James T. Inman, Taryn M. Kay, Joshua Jeong, Glenn Hauk, Deanna Gotte, James M. Berger, Mikhail Kashlev, Michelle D. Wang 2025-12-18 07:00:42

Extreme plate boundary localization promotes shallow earthquake slip at the Japan Trench

Science, Ahead of Print.

— J. D. Kirkpatrick, H. M. Savage, C. Regalla, S. Shreedharan, C. Ross, H. Okuda, U. Nicholson, K. Ujiie, R. Hackney, M. Conin, P. Pei, S. Satolli, J. Zhang, P. Fulton, M. Ikari, S. Kodaira, L. Maeda, N. Okutsu, S. Toczko, N. Eguchi, Expedition 405 Scientists†P. Bellanova, C. Brown, M. Brunet, M. R. Castillo, Y.-C. Chang, M.-L. Doan, J. Everard, A. Fintel, J. Ford, R. Fukuchi, A. Gough, H. Guo, D. Gürer, M. Hagino, Y. Hamada, H. Hosono, M.J. Jurado, A. Ijiri, T. Ishikawa, M. Iwai, T. Jeppson... 2025-12-18 07:00:42

Multistep genomics on single cells and live cultures in subnanoliter capsules

Science, Ahead of Print.

— Ignas Mazelis, Haoxiang Sun, Arpita Kulkarni, Theresa L. Torre, Allon M. Klein 2025-12-18 07:00:42

High-throughput single cell omics using semipermeable capsules

Science, Ahead of Print.

— Denis Baronas, Simonas Norvaisis, Justina Zvirblyte, Greta Leonaviciene, Vincenta Mikulenaite, Karolis Goda, Vytautas Kaseta, Karolis Sablauskas, Laimonas Griskevicius, Simonas Juzenas, Linas Mazutis 2025-12-18 07:00:42

Giant enhancement of exciton diffusion near an electronic Mott insulator

Science, Ahead of Print.

— Pranshoo Upadhyay, Daniel G. Suárez-Forero, Tsung-Sheng Huang, Mahmoud Jalali Mehrabad, Beini Gao, Supratik Sarkar, Deric Session, Kenji Watanabe, Takashi Taniguchi, You Zhou, Michael Knap, Mohammad Hafezi 2026-01-01 07:00:01

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

Science, Ahead of Print.

— Siddhant U. Jain, Kaylyn E. Williamson, Alexander W. Ying, Aasha M. Turner, Ruidong Jerry Jiang, Shaunak Raval, Kevin So, Maxwell J. Allison, Akshay Sankar, Daniel D. Sáme Guerra, Yutong Lin, Zhe Jiang, Nazar Mashtalir, Henry W. Rohrs, Cheryl F. Lichti, Tom W. Muir, Malvina Papanastasiou, Joao A. Paulo, Steven P. Gygi, Michael L. Gross, Cigall Kadoch 2026-01-01 07:00:01

A second planetesimal collision in the Fomalhaut system

Science, Ahead of Print.

— Paul Kalas, Jason J. Wang, Maxwell A. Millar-Blanchaer, Bin B. Ren, Mark C. Wyatt, Grant M. Kennedy, Maximilian Sommer, Thomas M. Esposito, Robert J. De Rosa, Michael Fitzgerald 2025-12-18 07:00:42

A precessing jet from an active galactic nucleus drives gas outflow from a disk galaxy

Science, Ahead of Print.

— Justin A. Kader, Vivian U, Loreto Barcos-Muñoz, Marina Bianchin, Sean T. Linden, Yiqing Song, Gabriela Canalizo, Archana Aravindan, George C. Privon, Tanio Díaz-Santos, Christopher Hayward, Matthew A. Malkan, Lee Armus, Rosalie C. McGurk, Jeffrey A. Rich, Anne M. Medling, Sabrina Stierwalt, Claire E. Max, Aaron S. Evans, Christopher J. Agostino, Vassilis Charmandaris, Tianmu Gao, Justin H. Howell, Hanae Inami, Thomas S.-Y. Lai, Kirsten L. Larson, Christopher D. Martin, Mateusz Matuszewski, ... 2026-01-08 05:15:00

Computational design of conformation-biasing mutations to alter protein functions

Science, Ahead of Print.

— Peter E. Cavanagh, Andrew G. Xue, Shizhong A. Dai, Albert Qiang, Tsutomu Matsui, Alice Y. Ting 2026-01-08 06:59:00

Mitochondrial control of fuel switching via carnitine biosynthesis

Science, Ahead of Print.

— Christopher Auger, Hiroshi Nishida, Bo Yuan, Guilherme Martins Silva, Masanori Fujimoto, Mark Li, Daisuke Katoh, Dandan Wang, Melia Granath-Panelo, Jihoon Shin, Rose Witte, Jin-Seon Yook, Anthony R. P. Verkerke, Alexander S. Banks, Sheng Hui, Lijun Sun, Shingo Kajimura 2026-01-08 06:59:00

Metallic θ-phase tantalum nitride has a thermal conductivity triple that of copper

Science, Ahead of Print.

— Suixuan Li, Chuanjin Su, Zihao Qin, Ahmet Alatas, Martin Kunz, Takahiro Yamada, Shelly D. Kelly, Mary H. Upton, Anthony Gironda, Jiyong Zhao, Bora Kalkan, Wanli Yang, Toshihiro Aoki, Yongjie Hu 2026-01-15 07:00:05

A genetically encoded device for transcriptome storage in mammalian cells

Science, Ahead of Print.

— Yu-Kai Chao, Michelle Wu, Qiyu Gong, Fei Chen 2026-01-15 07:00:05