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- Digital Fluorescent pH Probes: Polymer-Based Design, Fluorescence Response, Mechanism, Functional Tuning and Application to Logic Operation in Live Cells
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01187F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Seiichi Uchiyama, Eiko Hamada, Masaharu Takarada, Kohki Okabe
We report fluorescent digital pH probes based on a polymeric design comprising thermoresponsive, proton-binding and environment-sensitive fluorescent units. At selected temperatures, fluorescence switching was nearly complete, with a slight pH...
The conten... - Classification of small specimen uranium ores using LIBS combined with machine learning and deep learning algorithms
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01326G, PaperJingrong Li, Xiaoliang Liu, Ming Zhang, Xiangting Meng, Hua Rong, Shaohua Sun, Zuoye Liu, Chunyan Zou, Xiaoyang Guo
In this study, classification models based on Laser-induced breakdown spectroscopy (LIBS) technology, combined with machine learning (ML) and deep learning (DL) algorithms, were proposed to enable the rapid and high-precision...
The content of this RSS Feed (c) The Royal Society of Chemistry - Rapid screening of commercial CBD oils by heat-assisted dielectric barrier discharge ionization (HA-DBDI) mass spectrometry and correlation-based fingerprinting
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01179E, Paper Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Odhisea Gazeli, Marios C. Christodoulou, Nikolaos Argirusis, George E. Georghiou, Efstathios A. Elia, Agapios Agapiou
A HA-DBDI-MS workflow with correlation-based fingerprinting that enables rapid screening and grouping of commercial CBD oils. This offers a high-throughput quality control tool for assessing product authenticity and ph... - Sustainable, biodegradable paper sensor functionalized with oxidised bis(indolyl)methane for temporal discrimination of hazardous organophosphorus simulants in aqueous media
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01172H, PaperRikitha S. Fernandes, Nilanjan Dey
Oxidized bis(indolyl)methane probes enable temporal discrimination of organophosphorus (OP) simulants in water via phosphorylation, hydrogen bonding, and time-dependent Michael addition, and are integrated into biodegradable paper strips for sustainable visual sensing.
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The content of this RSS Feed (c) The Royal S... - Chemical Reaction-Enabled Lipidomics: From Sensitive Structural Analysis to Biomedical Applications
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01334H, Critical ReviewQirui Yu, Xiaoxiao Ma
Lipidomics has emerged as a vital discipline for understanding cellular metabolism and disease pathology. However, the immense structural diversity, wide dynamic range, and varying ionization efficiencies of lipids present significant...
The content of this RSS Feed (c) The Royal Society of Chemistry - DL-assisted self-volume-calibrating colorimetric PAAHM sensors for water surveillance
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01216C, PaperMiaorong Lin, Jihan Qu, Ting Xiao, Tingting Yang, Jiahui Chen, Jianxin Meng, Fengyu Li
The PAAHM-based colorimetric sensor enables large-scale synthesis while overcoming the constraints of fixed-volume sample addition. Integrated with digital imaging and CNN analysis, it provides accurate ion quantification in real water samples.
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The content of th... - Investigating the existing analytical methods deployed for leptospirosis detection and diagnostics
- Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00005C, Critical ReviewEmbar Prasanna Kannan, Prasanth Venkatachalam, Judy Gopal, Nazim Hasan, Manikandan Muthu
Analytical Palette available for Leptospirosis detection and future scope.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Carbon dot–MOF composites for cancer biomarker detection: an emerging research frontier
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00896D, Critical ReviewAdedibu C. Tella, Anthony O. Oyediran, Adetola C. Oladipo, Deborah Josiah, Oluwasegun A. Osatuyi, Tolulope M. Eluyera, Victor U. Ugwuanyi, Hadley S. Clayton, Margaret D. Olawale, Gift Mehlana, Oluwatobi S. Oluwafemi
Application of CD@MOF composites for biomarker sensing and integration for point-of-care diagnosis.
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The content of this RSS... - Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01258A, PaperQian Wang, Cong Luo, Jingyi Tang, Zhaolun Duan, Hui Pan, Huihui Wang, Haoyue Xiang, Hui Gu
Hydrogen sulfide (H2S) has emerged as a key neuromodulator in the central nervous system, yet its accurate quantification in the complex brain system remains challenging due to strong interference from...
The content of this RSS Feed (c) The Royal Society of Chemistry - Infrared microscopy of the biochemistry and metabolism in single living eukaryotic cells
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01213A, Critical ReviewLuca Quaroni
Infrared microscopy has evolved into a technique capable of quantitative measurements of biochemical reactions in single living cells.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Microplastic Detection and Recognition System Enabled by Triboelectric Nanogenerator and Machine Learning Techniques
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00014B, PaperPeyin Liu, Wei Long, Zhijie Zhang, Bin Li, Xiaolan Jia
The toxicity of microplastic pollutants is closely associated with their material, size, and concentration. However, current detection methods are plagued by issues such as high cost, long processing time, and...
The content of this RSS Feed (c) The Royal Society of Chemistry - Thermal desorption–photoionization ion mobility spectrometry for rapid analysis of tobacco flavorings and flavored filters
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01174D, PaperYajin He, Yating Yao, Yue Zhang, Yawen Guo, Huaiwen Cang, Weiguo Wang, Jinghua Li, Bing Wang, Shuang Wang, Wuduo Zhao
Integrated thermal desorption-photoionization ion mobility spectrometry enables the rapid identification of liquid flavorings and the quantitative detection and release monitoring of flavor additives in filter rods during industrial production.
To cite this article before page numbers are assigned, use the DOI form of c... - An anti-interference near-infrared SERS tag-aptamer sensor for rapid detection of Staphylococcus aureus in complex matrices
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01324K, PaperRui Zhao, Qishuo Wang, Yunqing Wang, Rongchao Mei, Xiaoyan Wang, Lingxin Chen
We report a near-infrared SERS sensor with superior anti-interference performance, which is accomplished by encapsulating SERS tags into a carboxylated polystyrene shell and covalently conjugating them to a target-specific aptamer.
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The content of this RSS Feed (c) The Ro... - Deterministic droplet-based co-encapsulation of single cells through inertial and hydrodynamic focusing
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00986C, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Byeong-Ui Moon, Lidija Malic, Dillon Da Fonte, Liviu Clime, Félix Lussier, Ljuboje Lukic, David Juncker, Teodor Veres
An on-chip, concentration-controlled encapsulation method is presented by combining inertial and hydrodynamic focusing. The experimentally measured interparticle distances are compared with theoretical p... - Initial testing procedure based on microextraction followed by LC-HRMS analysis to determine 107 xenobiotics and their metabolites in serum/plasma
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01329A, PaperMonica Mazzarino, Koen Deventer, Laurie De Wilde, Kris Roels, Peter Van Eenoo
A simple and sensitive microextraction protocol based on the use of unmodified cellulose was developed for the simultaneous extraction of 107 prohibited compounds and their metabolites from 20 µL of serum and plasma.
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The content of this RSS Feed (c) The Royal Society of... - Characterizing microscopic calcification deposits on acrylic intraocular lenses
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00999E, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cassandra L. Ward, S. Sameera Perera, Zhi Mei, Bing X. Ross, Manisha De Alwis Goonatilleke, Mahdi Ayoubi, Yao Xiao, Andrew P. Ault, Judy A. Westrick, Thomas H. Linz, Xihui Lin
Characterizing crystallized deposits on intraocular lenses is challenging due to the small, curved sample. Powder X-ray diffraction, Raman, XPS, a... - Targeted screening of natural thrombin inhibitors from herbal extracts using an enzyme-immobilized microfluidic reactor
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01290B, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xian-Na Wang, Ji Zhang, Yahui Song, Rui-Ping Song, Weiwei Tang, Bin Li
An enzyme-immobilized microfluidic reactor (EIMR) is a highly efficient platform for in vitro screening of catalysts and inhibitors. Herein, an EIMR integrated in a glass-PDMS hybrid microfluidic chip (HMC) was...
The content of this RSS Feed (c) ... - Recent Advances of Microneedle-Based Electrochemical Biosensors for Monitoring Biomarkers in Interstitial Fluid
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01250C, MinireviewRenqiang Yuan, Xiaoxin Ma, Guda Zou, Guohuang Zhou, Wei Li, Jia Liu, Yixin Xu, Shao Su, Lianhui Wang
Microneedle (MN)-based electrochemical biosensors have emerged as a revolutionary technology for minimally invasive diagnostic applications, particularly point-of-care (POC) monitoring of biomarkers in interstitial fluid (ISF). Featuring painless skin penetration, rapid...
The content of this RSS Feed (c) The Royal Society... - Dual-responsive fluorescence aptasensor for simultaneous detection of antibiotics and construction of molecular logic gates
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01366F, PaperJunbo Hu, Haonan Xu, Pengfei Sun, Yan-Qin Huang, Xingfen Liu, Quli Fan
The large-scale use of antibiotics in agriculture and husbandry has become a serious threat to the public health and environment. There is an urgent need to develop versatile sensing systems...
The content of this RSS Feed (c) The Royal Society of Chemistry - Vibrational spectroscopy for rapid profiling of vancomycin susceptibility in Enterococci
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01068C, CommunicationAva Rossetti, Xenia Kostoulias, Magdalena Giergiel, Jhih-Hang Jiang, Anton Y. Peleg, Kamila Kochan
ATR-FTIR spectroscopy detects early chemical responses to vancomycin, enabling rapid differentiation of vancomycin-susceptible and -resistant enterococci. This work establishes a label-free platform for accurate antimicrobial susceptibility testing.
To cite this article before page numbers are assigned, use the DOI form of citatio... - A reusable fluorescent biosensor based on a morphology-controlled ZIF-8⊃FAM-DNA film
- Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00017G, PaperXiaohu Wang, Dongjun Ren, Yangyi Liu, Yunqing Lu, Jin Wang
As a promising porous material, zeolitic imidazolate framework-8 (ZIF-8) exhibits significant application potential in biosensing.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Studying the evolutionary potential of ancestral aryl sulfatases in the alkaline phosphatase family with droplet microfluidics
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00865D, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bernard Eenink, Josephin M. Holstein, Magdalena Heberlein, Carina Dilkaute, Joachim Jose, Florian Hollfelder, Bert van Loo, Erich Bornberg-Bauer, Tomasz Kaminski, Andreas Lange
Characterizing the dynamics and functional shifts during protein evolution is essential, both for understanding protein evolution and for rationalizing eff... - Magnetic molecularly imprinted polymers-assisted target enrichment for fluorescence detection of chloramphenicol in water
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00075D, PaperZan Long, Jiajun Guo, Xiaofeng Liu, Caicheng Long, Peng Zhang, Bo Feng, Taiping Qing
The abuse of antibiotics has induced various environmental problems and poses a threat to human health and life. Fluorescence analysis method has received extensive attention in the fields of antibiotic...
The content of this RSS Feed (c) The Royal Society of Chemistry - Selective thin film microextraction of naproxen from biological and environmental matrices utilizing chitosan-derived bio-imprinted polymer with fluorescence detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00991J, PaperZahra Ayazi, Samira Pashayi Sarnaghi, Mays Ali Hassooni Al-najafi
This study presents the selective isolation of naproxen from complex matrices through thin film microextraction using a chitosan-derived molecularly imprinted polymer thin film, followed by quantification utilizing fluorescence spectroscopy.
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The content of this RSS Feed (c) The Roya... - A synergistic bimetallic MOF/MWCNT nanocomposite for sensitive electrochemical detection of baicalin
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01276G, PaperYijie Zhang, Yongxin Tao, Shan Li, Yong Qin, Jinmin Wang
The ZnNi-MOF@MWCNT sensor, through the synergistic effect of Ni, MWCNTs and the Zn-MOF, achieves highly efficient and selective detection of Bn and demonstrates excellent performance and application potential in actual serum samples.
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The content of this RSS Feed (c) The Royal Society of Chem... - Correction: Light-activated nanocomposite thin sheet for high throughput contactless biomolecular delivery into hard-to-transfect cells
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90082D, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hima Harshan Padma, Donia Dominic, Kavitha Illath, Srabani Kar, Tuhin Subhra Santra
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The content of this RSS Feed (c) The Royal Society of Chemistry - Versatile polymeric membrane ion-selective electrodes based on cellulose triacetate
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01364J, PaperLu Liu, Shusheng Liu, Rongning Liang, Wei Qin
Nowadays, polymeric membrane ion-selective electrodes (ISEs) based on poly(vinyl chloride) (PVC) matrix have been widely used in in clinical diagnosis and environmental monitoring. However, chemical inert of PVC may limit...
The content of this RSS Feed (c) The Royal Society of Chemistry - Untargeted mass spectrometry to investigate ocean acidification in Cancer borealis using optimized metabolite extraction methods
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00788G, PaperYunxiao Yao, Olga Riusech, Shuling Xu, Lingjun Li
Untargeted metabolomics reveals dynamic metabolic responses of Jonah crabs to ocean acidification, highlighting the utility of isopropanol extraction and the need for improved annotation of marine metabolites.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Thermodynamic and modeling insights of DNA molecular beacons with dual target binding to design for tunable fluorescent outputs
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01208B, PaperEsther E. Stopps, Stephanie E. McCalla
Multi-site molecular beacons (MBs) offer a versatile platform for detecting specific nucleic acid targets based on the relative proximity of fluorophore and quencher molecules.
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The content of this RSS Feed (c) The Royal Society of Chemistry - CRISPR/Cas13a-induced self-priming cyclic amplification enables liquid biopsy of exosomal circular RNA in non-small cell lung cancer
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01345C, PaperXiaodan Zhu, Guomin Gu, Yanli Shen, Mihray Abdurazik, Gang Sun
The precise and reliable identification of circular RNA (circRNA) is essential for both biological studies and clinical diagnostics of non-small cell lung cancer (NSCLC), especially the exosomal circRNA.
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The content of this RSS Feed (c) The Royal Society of Chemistry - An “off–on” electrochemiluminescence biosensor based on CRISPR-Cas12a for ultrasensitive determination of aflatoxin B1
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01369K, PaperZhi-Hong Xu, Xiao Hu, Xin Weng, Ruo-Mei Lin, Wen Xu, Li-Shuang Yu, Hang Gao
An aggregation-induced electrochemiluminescence sensor integrated CRISPR-Cas12a system is firstly reported for the detection of aflatoxin B1 (AFB1), demonstrating excellent analysis performance.
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The content of this RSS Feed (c) The Royal Society of Chemistry - One-Pot Ligation-PCR for Universal RNA Biomarker Detection
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01203A, PaperJinding Liu, Zhixin Xie, Nini Li, Jiajia Li, Minghua Zhang, Yongqiang Cheng, Jiangyan Zhang
In the detection of RNA biomarkers, conventional PCR-based workflows such as reverse transcription-PCR (RT-PCR) and ligation-PCR each exhibit inherent limitations. RT-PCR requires cDNA synthesis and often struggles with targets of...
The content of this RSS Feed (c) The Royal Society of Chemistry - A dual-modal 19F MRI / 18F PET approach using sultones derived chemical tags
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01102G, PaperAmaury Guillou, Nicolas Joudiou, Alice Fortin, Fabienne Gourand, Lionel Mignion, Bénédicte F. Jordan, Dominique Cahard, Cecile Perrio
Biocompatibility and hydrophilicity are key factors in the design of water-soluble imaging probes, particularly for 19F MRI, where perfluorocarbon contrast agents are typically highly hydrophobic. To address this limitation, two...
The content of this RSS Feed (c) The Royal Society of Chemistry - Resolving the chemical space: a legacy of recording separation science and innovation in Analyst
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90086G, EditorialLeon P. Barron, Brett Paull, Lihua Zhang
The Guest Editors introduce this Analyst 150th anniversary themed issue on separation science.
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The content of this RSS Feed (c) The Royal Society of Chemistry - An optical fiber crystal violet sensor using a porous ITO membrane coated on an optical fiber surface with UV photon-enhanced sensitivity
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01156F, PaperJosiah W. Miller, Shiquan Tao
Indium tin oxide (ITO) is an optically transparent semiconductor used in many optoelectronic devices. In this work, the porous property of an ITO membrane coated on the surface of a...
The content of this RSS Feed (c) The Royal Society of Chemistry - Design, preparation of microneedles and their applications in medical diagnosis and cosmetic regeneration
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01095K, MinireviewShanqi Bao, Huanhuan Shi, Weizheng Xu, Zidong Zhou, Shijie Qu, Xinyi Wang, Ziwen Cheng, Chen Huang
This review covers the classification and core traits of polymer-based microneedles, their mainstream preparation technologies, their applications in transdermal drug delivery, vaccine administration and skin disease treatment, and insights for overcoming clinical translation bottlenecks.
To cite this article before page numbers are ... - Förster Resonance Energy Transfer-Based Anion Responsive Nanoemulsion Optodes: Importance of Fluorescent Dye Liquid Lipophilicity and Ionophore-dye Interaction for Stable and Background-free Anion Response
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01097G, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daiki Matsumoto, Kenji Sueyoshi, Tatsuro Endo, Hideaki Hisamoto
In this study, we fabricated and evaluated a highly sensitive Förster Resonance Energy Transfer (FRET) based anion-responsive nanoemulsion optode (FRET-NE optode), using the originally-developed lipophilic fluorescent dye liquid. When the...
The content ... - Correction: Phage-ELISA for ultrasensitive detection of Salmonella enteritidis
- Analyst, 2026, 151,924-924
DOI: 10.1039/D6AN90004F, Correction Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mangmang Shen, Chang Ni, Jiasheng Yuan, Xin Zhou
The content of this RSS Feed (c) The Royal Society of Chemistry - Reduced drying times enable rapid paper spray analysis of whole blood for clinical toxicology
- Analyst, 2026, 151,741-748
DOI: 10.1039/D5AN01148E, Communication Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stefania Boccuzzi, David Cowan, Paul I. Dargan, Edward Goucher, Vincenzo Abbate
Drying whole blood spots for 10 minutes rather than 60 minutes gave equivalent performance by paper spray ionisation–mass spectrometry, preserving identification and quantitation, and enablingconfirmatory toxicology results within 15 minutes.
The cont... - Recent advances in Golgi-targeted fluorescent probes in ferroptosis research
- Analyst, 2026, 151,665-696
DOI: 10.1039/D5AN01240F, Critical ReviewShuai Wang, Wei Guo, Bo-Wen Wan, Kai-Ming Wang, Baoli Dong, Cheng-Shi Jiang, Juan Zhang
Ferroptosis, an iron-dependent modality of regulated cell death mediated by lipid peroxidation, has emerged as a central regulator of diverse pathologies, including tumorigenesis and neurodegeneration.
The content of this RSS Feed (c) The Royal Society of Chemistry - SPEC 2024: International Conference on Clinical Spectroscopy
- Analyst, 2026, 151,663-664
DOI: 10.1039/D5AN90089A, EditorialMartha Vardaki, Nikolaos Kourkoumelis
Martha Vardaki and Nikolaos Kourkoumelis introduce the Analyst themed collection on the SPEC24: International Conference on Clinical Spectroscopy.
The content of this RSS Feed (c) The Royal Society of Chemistry - Cobalt nanoparticle-encapsulated N-doped carbon nanotubes on 3D porous carbon: a novel platform for ultrasensitive electrochemical sensing of rutin
- Analyst, 2026, 151,913-923
DOI: 10.1039/D5AN01027F, PaperZhewei Zhang, Zijian Zhao, Yaqi Yang
This work develops an ultrasensitive electrochemical sensor for detecting rutin (Rt) using a composite material, Co@N-CNTs/3DHC.
The content of this RSS Feed (c) The Royal Society of Chemistry - A comprehensive review of C-reactive protein testing methods: from current status to future prospects
- Analyst, 2026, 151,718-740
DOI: 10.1039/D5AN01121C, Tutorial ReviewQian Zhou, Siying Pei, Shuo Yang, Tianwei Liu, Jiayi Wu, Zicheng Xu, Qixu Lu, Haixiao Fang, Qiong Wu
This paper systematically summarises C-reactive protein detection methods, elucidating the core principles and performance optimisation strategies of these techniques, with particular emphasis on emerging non-invasive detection approaches.
The content of this RSS Feed (c) The Royal Society of Chemistry - A photonic crystal sensing array based on a tandem CRISPR/Cas13a system for ultra-sensitive and high-throughput detection of the CVA6 virus
- Analyst, 2026, 151,903-912
DOI: 10.1039/D5AN01178G, PaperLinyao Wang, Liqian Su, Wanjiang Gu, Shujun Nie, Jie Luo, Yongru Li, Ao Pan, Yongxin Li
A tandem CRISPR/Cas13a system coupled with a photonic crystal array enables ultra-sensitive, high-throughput detection of CVA6.
The content of this RSS Feed (c) The Royal Society of Chemistry - Research on a spatiotemporal prediction method for two-dimensional temperature fields based on TDLAS array sensors and the SwinLSTM model
- Analyst, 2026, 151,892-902
DOI: 10.1039/D5AN01304F, PaperYongxin Hou, Rui Jia, Shenxiang Feng, Yanlin Wu, Pan Pei, Junjie Ma, Biming Mo, Hongkai Wei, Xiaojian Hao
Use of an array sensor to obtain complete two-dimensional spatial information of a flame, combined with a SwinLSTM model for spatiotemporal prediction.
The content of this RSS Feed (c) The Royal Society of Chemistry - Recent advances in highly sensitive and specific functional nucleic acid sensors for environmental pollutant detection: from mechanism to application
- Analyst, 2026, 151,697-717
DOI: 10.1039/D5AN01139F, Critical ReviewXue Yang, Huibin Wu, Zhi Zeng, Wen-na Chen, Guang-Xiang Luan, Qiu-long Zhang, Jian-min Chen
Functional nucleic acids (FNAs)—aptamers, RNA-cleaving DNAzymes, G-quadruplex/hemin DNAzymes, gRNAs—are cutting-edge tools for environmental pollutant detection, featuring exceptional stability, specificity, and signal transduction/amplification.
The content of this RSS Feed (c) The Royal Society of Chemistry - Study on temperature-responsive characteristics of reactant ions in corona discharge ion mobility spectrometry
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01135C, PaperJie Peng, Jingxiong Yu, Changwu Dong, Yihuang Jiang, Hui Xu, Hongtao Liu, Yuan Qian, Zejie Fei
Corona discharge ion mobility spectrometry was used to show the relationship between temperature and hydrated cluster ions. Experiments and calculations revealed temperature-dependent patterns in the stability of ion hydration structures in air.
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The cont... - Construction of hollow double shell NiMn PBA nanozymes for sensitive sarcosine detection via a cascade strategy
- Analyst, 2026, 151,786-793
DOI: 10.1039/D5AN01252J, PaperYiwen Sun, Ying Xie, Zixuan Yuan, Yujiao Mao, Huiru Liu, Yiting Zhu, Jinyu Dong, Xiaojun Chen
A novel NiMn-PBA-DSNB nanozyme was designed to realize sensitive sarcosine detection via an “enzyme–nanozyme” cascade reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry - Exploiting Pfu DNA polymerase's differential bypass capacity for AP vs. dU sites: a novel strategy for sensitive uracil-DNA glycosylase detection
- Analyst, 2026, 151,767-774
DOI: 10.1039/D5AN01082A, PaperRun-Hong Zhang, Chen-Yu Xue, Jia-Hui Dong, Xu-Yang Shen, Yi-Xuan Gu, Ying Liu, Ying-Lin Zhou, Xin-Xiang Zhang
A novel UDG assay exploiting the differential bypass capacity of Pfu DNA polymerase for AP sites over dU sites enables sensitive detection.
The content of this RSS Feed (c) The Royal Society of Chemistry - Gas-phase esterification within a miniature ion trap mass spectrometer: mechanistic insight and diagnostic markers for quinolone screening
- Analyst, 2026, 151,775-785
DOI: 10.1039/D5AN01210D, PaperWei Wang, Baokun Yang, Jie Hong, Xinhui Yu, Baoqiang Li, Wei Xu, Yanbing Zhai
A gas-phase SN2 esterification reaction between quinolone and alcohol molecules is occurred in a linear ion trap during collision-induced dissociation, where generated adduct ions could be used as diagnostic markers for quinolone screening.
The content of this RSS Feed (c) The Royal Society of Chemistry - Allium macrostemon bunge-like manganese tetroxide composite for sensitive detection of dopamine in human biological samples
- Analyst, 2026, 151,860-869
DOI: 10.1039/D5AN01111F, PaperZhenyu Cheng, Haobin Hu, Ximei Long, Huimin Yue, Zhijun Li, Yun Wu, Xiaoxia Wei, Haiyan Song
A three-dimensional (3D) composite material, which mimics Allium macrostemon bunge-like manganese (Mn) tetroxide (amb-Mn3O4), was prepared utilizing a simple one-pot hydrothermal method.
The content of this RSS Feed (c) The Royal Society of Chemistry - A silicon doped carbon dot-based fluorescent sensor for doxorubicin detection
- Analyst, 2026, 151,816-821
DOI: 10.1039/D5AN01122A, PaperShixiang Dong, Lin Zhang, Jia Ge, Xilin Dong, Haoran Liu, Changyu Wang, Zhaohui Li
A simple and highly sensitive fluorescent nanosensor for DOX assay based on Si-CDs.
The content of this RSS Feed (c) The Royal Society of Chemistry - Smartphone-assisted PEI@Eu-MOF lateral flow immunosensor for dual-modal POC detection of carbendazim
- Analyst, 2026, 151,749-759
DOI: 10.1039/D5AN01112D, PaperLingling Li, Doudou Lei, Pengyue Song, Qingbin Xu, Lihua Huang, Xiao Ma, Lidong Zhou, Ping Zhang, Weijun Kong
Sensitive detection of carbendazim (CBZ), a widely monitored bactericidal pesticide globally, is critical to reduce risks to human health.
The content of this RSS Feed (c) The Royal Society of Chemistry - Precision silver carp allergy profiling and rapid IgE epitope mapping by a microfluidic chip-MALDI-TOF MS system and prediction models
- Analyst, 2026, 151,878-891
DOI: 10.1039/D5AN01161B, PaperWinnie C. Soko, Chunqian Zuo, Ruirui Xu, Fang Lin, Qin Qin, Jing Xie, Hongyan Bi
Food allergies are increasing at an alarming rate, and it has become necessary to identify patient-specific allergens for personalized allergy immunotherapy treatments.
The content of this RSS Feed (c) The Royal Society of Chemistry - A cascaded catalytic hairpin 3D DNA walker-assisted dual-targeting biomimetic sensor for intracellular microRNA imaging
- Analyst, 2026, 151,870-877
DOI: 10.1039/D5AN01152C, PaperLanlan Jia, Jialin Guo, Min Li, Tingting Zhang, Yihan Sun, Yuxin Chen, Xiaoyu Xie, Qi Hu
Schematic representation of a dual-targeting biomimetic sensor for intracellular miRNA-21 imaging.
The content of this RSS Feed (c) The Royal Society of Chemistry - Triggering isothermal exponential amplification of microRNA via liposome fusion
- Analyst, 2026, 151,842-850
DOI: 10.1039/D5AN01087J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mamiko Tsugane, Kosuke Kato, Keisuke Shinohara, Tsutomu Okita, Reiko Sato, Hiroaki Suzuki
Lipid vesicle fusion was used to trigger miRNA-initiated isothermal amplification (EXPAR) inside GUVs. This system enables real-time detection of membrane-encapsulated RNA and offers potential for artificial cells and vesicle-based diag... - Creating taxonomically-informed metabolome libraries for any species using the pubchem.bio R package
- Analyst, 2026, 151,851-859
DOI: 10.1039/D5AN00914F, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Corey D. Broeckling
The pubchem.bio R package enables efficient subsetting of PubChem, retaining only biologically associated structures, and further subsetting and scoring via taxonomy to enable the creation of species-specific metabolite libraries.
The content of this RSS Feed (c) The Royal Society of Chemistry - Liquid–liquid phase separation-assisted Raman microscopy for sensitive and label-free analysis of enzymatic reactions and protein–small molecule interactions
- Analyst, 2026, 151,807-815
DOI: 10.1039/D5AN00973A, PaperLisa Kageyama, Shinya Tahara, Reona Tobita, Shinji Kajimoto, Takakazu Nakabayashi
High-concentration PEG-based liquid–liquid phase separation concentrates biomolecules into droplets, enabling highly sensitive, label-free Raman analysis of enzymatic reactions and protein–small-molecule interactions in dilute, small-volume samples.
The content of this RSS Feed (c) The Royal Society of Chemistry - On-chip filtration enrichment and ultrasensitive nanozyme-catalyzed colorimetric detection of Streptococcus pneumoniae in saliva samples
- Analyst, 2026, 151,830-841
DOI: 10.1039/D5AN00879D, PaperYuancheng Guo, Zhijie Tu, Hong Chen, Hongjuan Wei, Tianci Wang, Guohui Sun, Zhen Rong
A filter membrane-integrated microfluidic immunosensor for nanozyme-catalyzed detection of S. pneumoniae in clinical samples.
The content of this RSS Feed (c) The Royal Society of Chemistry - A near-infrared benzothiazole-based fluorescent probe for selective detection of CORM-3 with a large Stokes shift in living cells
- Analyst, 2026, 151,822-829
DOI: 10.1039/D5AN01196E, PaperLiqiang Yan, Junjie Yang, Yanxin Zhang, Ying Sun, Jianmei Zou
This work develops a NIR fluorescent probe for sensitive CORM-3 tracking in living cells and on-site via test strips, offering a robust tool to study CORM-3 biology and therapeutic potential.
The content of this RSS Feed (c) The Royal Society of Chemistry - A portable smartphone assisted multi-color colorimetric sensor for the detection of mercury ions based on the peroxidase-like activity of platinum nanoparticles
- Analyst, 2026, 151,760-766
DOI: 10.1039/D5AN01167A, PaperShasha Wang, Huiqing Zhang, Li Wang, Chaonan Huang, Jiping Ma, Liyan Wang, Xiaoyan Wang, Lingxin Chen
A portable smartphone-assisted multi-color colorimetric method for Hg2+ detection based on Hg2+-modulated peroxidase-like activity of PtNPs.
The content of this RSS Feed (c) The Royal Society of Chemistry - Ionic liquid-based dual-mode nano-optode for ultra-sensitive detection of perchlorate ions
- Analyst, 2026, 151,794-806
DOI: 10.1039/D5AN01064K, PaperSubekchha Pradhan, Upika Darnal, Shraddha Rai, Shubham Lama, Ashish Rai, Rifath Darjee, Najmin Tohora, Sabbir Ahamed, Sudhir Kumar Das
An orange light-emitting ionic liquid (IL), XBIL, and its dual-mode nano-optode, nXBIL, have been introduced for detection of perchlorate (ClO4−) ions having limits of detection (LOD) and quantification (LOQ) in the nanomolar range.
The content of this RSS Feed (c) The Royal Society of Chemistry - Integration of Raman Tweezers and Machine Learning for Label-Free Single-Cell Characterization of Endometriosis Cells
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01076D, PaperHien Dinh Nguyen, N/A Asaduzzaman , Ajitesh Dhal, Bashir Danmahawayi Zubairu, Chang-I Chen, J. Timothy Qiu, Zhao-Chi Chen, Tzu-Sen Yang
Endometriosis occurs when endometrial tissue grows outside the uterus, affecting millions of women worldwide. Despite extensive research, its cellular mechanisms remain unclear, complicating both diagnosis and treatment. This study presents...
The content of this RSS Feed (c) The Royal Society ... - An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor for highly sensitive detection of hypochlorous acid
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01299F, PaperXin Liu, Xiangyue Wang, Shaoying He, Mingxi Li, Chunhua Lu, Chao Xing
An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor was constructed for HClO detection.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Structure-adaptive dual-function poly-T sequences enable homogeneous label-free colorimetric sensing platform
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01335F, PaperShao-Yu Sun, Yi Song, An-Qi Xiao, Xin-Yan Zhang, Xu-Xia Yan, Huidong Qiu, Qianyu Zhou
Compared with the extensive research on G-rich nucleic acids, the catalytic properties of T-rich sequences have received limited attention. Herein, the peroxidase-like activity of poly-T sequences was investigated, and the...
The content of this RSS Feed (c) The Royal Society of Chemistry - Comparative Studies for Conventional and AI Methods for Sugar, Food, Textile, and Pharmaceutical Industries Wastewater Treatment: A Review
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00975H, Critical ReviewShagufta Jabin, Ritu Bir, Sadiqa Abbas, Jyoti Chawla, Anisha ., Sapana Jadoun
Industrial wastewater treatment in sectors such as food, sugar, textiles, and pharmaceuticals has attracted interest in the use of traditional methodologies in combination with Artificial Intelligence (AI). This combination of...
The content of this RSS Feed (c) The Royal Society of Chemistry - MXene-based fluorescent aptasensors: advances and prospects in diagnostics and environmental monitoring
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00945F, Minireview Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rajapriya Govindaraju, Jongsung Kim
MXene-based fluorescent aptasensors for diagnostics and environmental monitoring.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Improved NMR-based diffusion measurements for inorganic ions
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01232E, PaperMaria Clara D. N. G. Leal, Binhan Yu, Tianzhi Wang, Junji Iwahara
The most widely used NMR method to measure diffusion is suboptimal for inorganic ions. A robust and superior alternative is available when strong field gradients (>1000 G/cm) can be used.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Temporal SERS quantification and the chemometric monitoring of amikacin release in blood serum from a stimuli-responsive drug carrier: kinetics modeling and in-vitro pharmacodynamic evaluation
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01153A, PaperAnfal Fatima, Nasir Mehmood, Ali Akbar, Abdul Naman, Mohammed Alissa, Ghadah S. Abusalim, Adil Abalkhail, Minseok Kim
The controlled delivery of antibiotics from stimuli-responsive hydrogels is a promising approach, although controlled release kinetics and pharmacodynamic (PD) outcomes are very challenging to measure accurately.
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The content of thi... - Recent advances in MXene nanozymes: synthesis, surface modifications, catalytic properties, and their emerging roles in biosensing and therapeutic applications
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01137J, Tutorial ReviewHatem A. Al-Aoh, Chellasamy Panneerselvam, Asim. M. Alghamdi, Abdulrahman Alasmari, Zuhair M. Mohammedsaleh
MXene nanozymes have emerged as an important class of nanomaterials, bridging materials science, chemistry, and biomedicine with their exceptional catalytic properties, tunable surface chemistry, and multifunctionality.
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The content... - Integrated microfluidic device for rapid and accurate point-of-care detection of high-risk HPV16 and HPV18
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01244A, PaperNatish Kumar, Monika Kumari, Devtulya Chander, Sandeep Dogra, Asha Chaubey, Ravi Kumar Arun
Integrated microfluidic LAMP-LFA platform for on-chip HPV nucleic acid extraction, amplification, and lateral-flow detection.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Ambient ionization strategies for the characterization of microbial systems via mass spectrometry
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01214G, Minireview Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hawkins S. Shepard, Jody C. May, John A. McLean
This minireview focuses on the most important developments in the field of ambient ionization mass spectrometry applications to microbial samples reported in the last five years.
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T... - Quantification of buparlisib in human liver microsomes employing an ultra-fast, sensitive UPLC-MS/MS method: in vitro and in silico metabolic stability evaluation
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01155H, PaperMohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi
Buparlisib exhibited a moderate extraction ratio, with a Clint of 32.24 mL min−1 kg−1 and a t1/2 of 25.15 min. Small changes of the 2-aminopyridine (58%) and morpholine (42%) moieties in buparlisib may increase stability and enhance safety profile.
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The content of this RSS Fe... - In situ synthesis of gold-core silver-shell nanoparticles on bacterial cellulose for SERS detection of micro- and nanoplastic particles in vegetables
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01043H, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Seyedehalaleh Kousheh, Azlin Mustapha, Mengshi Lin
Micro- and nanoplastic particles (MNPs) are ubiquitous environmental contaminants, raising significant concerns due to their potential health risks.
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The content of this RSS Feed (c) ... - An electrochemical immunosensor based on MXene–Au and Au–Ce-COF to detect methyl parathion
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01289A, PaperPeiyao Zhu, Deyu Liu, Yaqi Chen, Haiping Huang, Fang Xu
An electrochemical immunosensor based on MXene nanosheets loaded with AuNPs (MXene–Au) and a cerium-doped covalent organic framework loaded with AuNPs (Au–Ce-COF) was constructed and applied for the ultra-sensitive detection of methyl parathion.
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The content of this RSS Feed (c) The Royal ... - Selective Electrochemical Discrimination of 3’ IsomiRs Differing by Two Nucleotides
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01292A, PaperJulio Ojeda, Nicholas Bruno, Karen Cover, Wencai Zhang, Karin Chumbimuni-Torres
MicroRNAs and isomiRs are promising biomarkers for the detection of diseases such as cancers, but distinguishing the highly similar microRNAs sequences between these remains challenging. We report a five-strand four-way...
The content of this RSS Feed (c) The Royal Society of Chemistry - 3D-printed hollow microneedle-based electrochemical sensor for wireless glucose monitoring
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01058F, PaperChuchu Chen, Yonghao Fu, Yuehe Lin, Yun Liu, Dan Du, Kaiyan Qiu
A wearable electrochemical sensor combining a 3D-printed hollow microneedle array, a finger-activated pump, and single-atom nanozymes for highly sensitive glucose monitoring.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Visualization of heated latent fingerprints by synchrotron radiation soft X-ray photoemission electron microscopy
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01158B, PaperSatoru Hamamoto, Masahisa Takatsu, Hiroyuki Fujiwara, Hideya Okada, Takuo Ohkochi, Shimpei Watanabe, Masaki Oura, Yasuo Seto
Synchrotron radiation soft X-ray photoemission electron microscopy can clearly reveal ridge patterns by specifically and sensitively detecting sodium elements in heated fingerprints, which cannot be visualized by usual observation techniques.
To cite this article before page numbers are assigned, use the DOI form... - A Direct Comparison of Antibody and nanoMIP Affinities using Surface Plasmon Resonance and Electrochemical Techniques: A Haemoglobin Model
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01205H, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Subrayal M Reddy, Andrei N Stephen, Barbara V Boldrin
This study presents, for the first time, a direct quantitative comparison between the binding affinities and selectivity of antibodies and their molecularly imprinted polymer (nanoMIP) counterparts for a target protein...
The content of this RSS Feed (c) The Royal ... - Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning for lactic acid bacteria identification at strain level
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01093D, PaperPaul Lagneaux, Nathan Widjaja, Bastien Lagneaux, Thi Kim Chi Nguyen, Hélène Licandro, Pascale Winckler, Yves Waché
Lactic acid bacteria (LAB) are widely used in food, health, and biotechnology sectors. Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning is explored for improved strain level identification.
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The conten... - Flow solitons of supermolecular complex DEAE-dextran-MMA copolymer/small noncoding RNAs for epigenetic change from cancer to normal cells in TME
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00375J, PaperOxana V. Klimenko, Rui-Cheng Ji, Masayasu Onishi, Masaaki Mizuno, Naoji Kubota, Yuki Eshita, Yasuhiko Onishi
DDMC (DEAE-dextran-MMA copolymer)/sncRNAs (a-miR-155, piR-30074, and miR-125b) complex completely cured mice with virus-induced sarcoma after cellular reprogramming treatment, transforming cancer cells into normal cells.
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The content of this... - Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01100K, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sandra Adámez-Rodríguez, María Luisa Marina, María Castro-Puyana
An EKC method using sulfated-γ-cyclodextrin and short-end injection enabled the rapid enantiomeric separation of 5-HTP for dietary supplement quality control.
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The ... - Development of a PCB-based electrochemical aptasensor for Chikungunya virus protein detection
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01261A, PaperSyama Sajikumar, Naveenkumar Sureshkumar, V. V. R. Sai, Verma Jyoti, Sujatha Sunil, Ramanathan Srinivasan
Chikungunya E1 protein detection with 10 pM LOD was achieved with a 10 μL sample on a printed circuit board aptasensor. The hexaammine ruthenium redox couple does not attack the Au layer, enables regeneration, and yields reproducible results.
To cite this article before page numbers are assigned, use the DOI form of citation above... - Pyrrolidone modified magnetic COF materials for the quantitative determination of 25-hydroxyvitamin D in human serum via isotope dilution mass spectrometry
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01098E, PaperXiaojie Zhang, Jixing Huang, Yazhou Han, Wentao He, Chuan-fan Ding, Yinghua Yan
A magnetic COF material modified with pyrrolidone and p-aminobenzoic acid was developed for quantifying 25-hydroxyvitamin D from serum via isotope dilution mass spectrometry.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Systematic evaluation of pre-analytical variables on synovial fluid metabolomic profiles using GC-ToF-MS and UHPLC-MS
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00943J, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yumna Ladha, Adam Burke, Nigel Gotts, Royston Goodacre, Karina Wright, Jade Perry, Charlotte H Hulme
This work reveals the critical influence of sample preparation methods on synovial fluid metabolome characterisation.
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The content of... - Targeted Serum Metabolomics Reveals Alterations in Amino Acid and Neurotransmitter Pathways in Parkinson's Disease
- Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00961H, PaperJiaxin Yang, Dong Wu, Zhiwei Wang, Zhijing Zhang, Xiaowen Zheng, Sheng Wang, Fen Huang, Shuai Song, Qunlin Zhang
Serum metabolomic profiling in Parkinson’s disease (PD) remains underexplored. This study characterized alterations in serum amino acid and neurotransmitter levels in PD using targeted metabolomics and identify associated dysregulated metabolic...
The content of this RSS Feed (c) The Royal Society of Chemistry - FeS-loaded nitrogen-doped carbon nanozymes for sensitive colorimetric detection of xanthine in urine samples
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01306B, PaperXueying Zhu, Shuo Tian, Shuyun Chen, Yunsen Wang, Dianping Tang
A simple and feasible colorimetric sensing platform was designed to detect xanthine in urine samples using FeS-loaded nitrogen-doped carbon nanozymes.
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The content of this RSS Feed (c) The Royal Society of Chemistry - Evaluation of ToF-SIMS imaging for semi-quantitative mapping of BODIPY-labeled fibronectin surface gradients
- Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00962F, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chao Liu, Tae Kyong John Kim, Douglas H. Wu, Radhika Atit, Rodrigo A. Somoza, Samuel E. Senyo
A novel semi-quantitative imaging mass spectrometry approach using ToF-SIMS enables high-resolution, sensitive mapping of fibronectin gradients in microfluidic haptotaxis assays beyond the limits of fluorescence microscopy.
To cite this articl... - A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models
- Analyst, 2026, 151,453-457
DOI: 10.1039/D5AN01169H, CommunicationLifang Guo, Yuxi Ding, Haijiao Wu, Qianxin Long, Zhiyun Zhang, Jianhua Su
A conformation-dependent bifunctional sensor is developed by capitalizing on a vibration-induced emission chromophore for viscosity sensing and an acid-triggered oxazolidine switch for pH sensing.
The content of this RSS Feed (c) The Royal Society of Chemistry - Multimodal analytical approaches to nanomaterials: TEM, diffraction, image processing, and fractal analysis
- Analyst, 2026, 151,327-355
DOI: 10.1039/D5AN00892A, Tutorial ReviewVadim Volochaev, Arshak A. Tsaturyan
Diverse experimental and computational methods is a productive approach and the most effective route to comprehensive material characterization.
The content of this RSS Feed (c) The Royal Society of Chemistry - Protein-targeted aptamers in liquid biopsy: from efficient screening to precise cancer diagnosis
- Analyst, 2026, 151,275-299
DOI: 10.1039/D5AN00864F, Critical ReviewWenjuan Xu, Qingyang Liu, Na Sun, Tian Gao, Renjun Pei
The schematic of early and precise cancer diagnosis based on aptamers selected using SELEX.
The content of this RSS Feed (c) The Royal Society of Chemistry - AQbD-driven UHPLC method for simultaneous quantification of budesonide, glycopyrronium bromide, and salbutamol sulphate: a unified approach for inhalation product and bioanalytical applications
- Analyst, 2026, 151,610-622
DOI: 10.1039/D5AN01086A, Paper Open Access  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alessio Gaggero, Dalibor Jeremic, Anna Fedorko, Jesús Alberto Afonso Urich
Inhalation therapies often combine budesonide, glycopyrronium bromide, and salbutamol sulphate, necessitating analytical methods capable of their simultaneous quantification.
The content of this RSS Feed (c) The Royal Society of Chemistry - Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy
- Analyst, 2026, 151,577-588
DOI: 10.1039/D5AN01114K, Paper Open Access  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zohreh Mirveis, Nitin Patil, Hugh J. Byrne
Understanding dynamic metabolic processes is central to elucidating cellular function and disease mechanisms.
The content of this RSS Feed (c) The Royal Society of Chemistry - From design to application: developments and challenges of nanomaterial-based optical biosensors for Salmonella detection
- Analyst, 2026, 151,300-326
DOI: 10.1039/D5AN00910C, Tutorial ReviewBin Wang, Yuan Tian, Zerun Zhang, Tianhan Kai, Jun Xiang, Pian Wu, Ping Ding
This review offers a unified “materials–structure–performance” perspective on nanomaterial-based optical biosensors for rapid Salmonella detection, and summarizes key elements and design principles that enable sensitive and portable sensing.
The content of this RSS Feed (c) The Royal Society of Chemistry - Surface charge engineering enhances symmetry and reliability of nanopores formed via dielectric breakdown
- Analyst, 2026, 151,597-609
DOI: 10.1039/D5AN00882D, PaperGuohao Xi, Gang Hu, Jie Ma, Lingzhi Wu, Jing Tu
Variations in the electrical properties of modified layers induce distinct changes in electron cloud distribution.
The content of this RSS Feed (c) The Royal Society of Chemistry - Advances and innovations in machine learning-based spectral detection methods for trace organic pollutants
- Analyst, 2026, 151,356-388
DOI: 10.1039/D5AN00903K, Tutorial ReviewYiheng Qin, Qiannan Duan, Haoyu Wang, Yonghui Bai, Yihao Qin, Liulu Yao, Fan Song, Mingzhe Wu, Jianchao Lee
The rapid and sensitive detection of trace organic pollutants in water is crucial for ensuring environmental safety.
The content of this RSS Feed (c) The Royal Society of Chemistry - Precise Klebsiella pneumoniae carbapenem resistance prediction by Zn–Cu/MOF-embedded hybrid nanosheet-assisted carbapenemase activity analysis
- Analyst, 2026, 151,498-507
DOI: 10.1039/D5AN00967G, PaperChenyao Lin, Qiaoping Wu, Menglu Mao, Xuedan Qiu, Chuanfan Ding, Yinghua Yan, Dumei Ma, Qingcao Li
A novel GNP@Zn–Cu/MOF@Au nanocomposite enables rapid and sensitive detection of carbapenemase activity by MALDI-TOF MS, offering a promising tool for clinical antimicrobial resistance testing.
The content of this RSS Feed (c) The Royal Society of Chemistry - Liposome array on a power-free microfluidic device for analysis of nanopore formation
- Analyst, 2026, 151,489-497
DOI: 10.1039/D5AN01113B, PaperMaho Hosokawa, Yiting Zhang, Masaki Ohtawa, Naoki Sasaki
A power-free microchannel-based platform that can accommodate numerous liposomes enables real-time analysis of Amphotericin B-induced nanopore formation, providing a high-throughput tool for screening enhancers and inhibitors of drug activity.
The content of this RSS Feed (c) The Royal Society of Chemistry - Smartphone-based fluorescence detection of 2,4-dichlorophenoxyacetic acid using ImageJ analysis on a molecularly imprinted membrane/carbon-dot system via a Schiff-base method
- Analyst, 2026, 151,636-649
DOI: 10.1039/D5AN00842E, PaperMuhammad Sajjad, Wijitar Dungchai, Nisakorn Thongkon
A novel smartphone-assisted fluorescence sensing platform using a molecularly imprinted PVDF/N-CDs composite membrane enables selective and sensitive detection of 2,4-D.
The content of this RSS Feed (c) The Royal Society of Chemistry - Identification of organochlorides in distilled fractions of plastic pyrolysis oil using GC × GC coupled with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS) and GC coupled with a halogen selective detector (GC-XSD)
- Analyst, 2026, 151,466-477
DOI: 10.1039/D5AN00852B, PaperBruno da Costa Magalhães, Pascal Pijcke, Niels Verhoosel, Philip Janssen, Cesare Benedetti, Matthijs Ruitenbeek, Georgios Bellos, Melissa N. Dunkle
A crude plastic pyrolysis oil was distilled into fractions with intervals of 50 °C. By combining different analytical capabilities, several organochlorides were speciated across the distilled fractions.
The content of this RSS Feed (c) The Royal Society of Chemistry
