Proteoform: Difference between revisions
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Smith LM, Kelleher NL; Consortium for Top Down Proteomics. Proteoform: a single term describing protein complexity. Nat Methods. 2013;10(3):186-187. {{doi}}10.1038/nmeth.2369 | |||
"1. A specific molecular form of a protein product arising from a specific gene: to measure a specific proteoform from a cell. | |||
2. Pl. Highly related protein molecules arising from all combinatorial sources of variation giving rise to products arising from a single gene. These include products differing due to genetic variations, alternatively spliced RNA transcripts, and post-translational modifications. | |||
3. The term includes all PTMs classified by the PSI-MOD ontology (which uses PSI-MS standardized names for protein modifications), except those classified as children of reagent derivatized residues (MOD:00848) or isotope labeled residues (MOD:00702). (http://www.unimod.org/names.html )." </code> | |||
[[Category:Proteomics]] | |||
Latest revision as of 21:02, 19 August 2025
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External links
Smith LM, Kelleher NL; Consortium for Top Down Proteomics. Proteoform: a single term describing protein complexity. Nat Methods. 2013;10(3):186-187. http://dx.doi.org/10.1038/nmeth.2369
"1. A specific molecular form of a protein product arising from a specific gene: to measure a specific proteoform from a cell.
2. Pl. Highly related protein molecules arising from all combinatorial sources of variation giving rise to products arising from a single gene. These include products differing due to genetic variations, alternatively spliced RNA transcripts, and post-translational modifications.
3. The term includes all PTMs classified by the PSI-MOD ontology (which uses PSI-MS standardized names for protein modifications), except those classified as children of reagent derivatized residues (MOD:00848) or isotope labeled residues (MOD:00702). (http://www.unimod.org/names.html )."
