Hydrogen/deuterium exchange: Difference between revisions

Latest revision as of 17:54, 1 April 2024

Hydrogen/deuterium exchange (HDX)
IUPAC RECOMMENDATIONS 2013
Exchange of hydrogen atoms with deuterium atoms in a chemical species in solution prior to introduction into a mass spectrometer, or by ion/molecule reaction with a neutral gas inside a mass spectrometer.
Related Term(s):
Reference(s): W. Blum, E. Schlumpf, J. G. Liehr, W. J. Richter. Tetrahedron Lett. 17, 565 (1976). (http://dx.doi.org/10.1016/S0040-4039(00)77911-1 ) S. Sethi, D. Smith, J. McCloskey. Biochem. Biophys. Res. Commun. 112, 126 (1983). (http://dx.doi.org/10.1016/0006-291X(83)91806-5 )
From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.
Index of Recommended Terms

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-{{DefName|
+{{Final
-A technique used for exploring the conformational structure of analyte by means of the surface accessibility with a deuterated reactant. The deuterium-labeling reaction is carried out either in the gas-phase inside a [[mass spectrometer]] or in the solution-phase prior to introduce the sample into a [[mass spectrometer]].
+|acronym=(HDX)
+|def=Exchange of [[wikipedia:hydrogen|hydrogen]] atoms with [[wikipedia:deuterium|deuterium]] atoms in a chemical species in solution prior to introduction into a [[mass spectrometer]], or by [[ion/molecule reaction]] with a neutral gas inside a mass spectrometer.
+|rel=
+|ref=W. Blum, E. Schlumpf, J. G. Liehr, W. J. Richter. Tetrahedron Lett. 17, 565 (1976). (http://dx.doi.org/10.1016/S0040-4039(00)77911-1 )
+S. Sethi, D. Smith, J. McCloskey. Biochem. Biophys. Res. Commun. 112, 126 (1983). (http://dx.doi.org/10.1016/0006-291X(83)91806-5 )
 }}
-{{Disc}}
 [[Category:Reactions]]
+[[Category:Isotopic labeling]]