Category:Reaction monitoring: Difference between revisions

IUPAC reaction monitoring terms

Term	Acronym	Definition	Diagram	Reference
Selected ion monitoring	SIM	Operation of a mass spectrometer in which the abundances of ions of one or more specific m/z values are recorded rather than the entire mass spectrum.		Gold Book
Selected reaction monitoring	SRM	Data acquired from one or more specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. Note 1: Selected reaction monitoring in multiple-stage mass spectrometry is known as consecutive reaction monitoring. Note 2: Selected reaction monitoring applied to multiple product ions from one or more precursor ions is known as multiple reaction monitoring.		de Hoffmann. J. Mass Spectrom. 31, 129 (1996).
Consecutive reaction monitoring	CRM	Multiple-stage mass spectrometry experiment with three or more stages of m/z separation in which products of sequential fragmentation or bimolecular reactions are selected for detection.		Tomer, Guenat, Deterding. Anal. Chem. 60, 2232 (1988).
Multiple reaction monitoring	MRM	Application of selected reaction monitoring to multiple product ions from one or more precursor ions. Note: This term should not be confused with consecutive reaction monitoring, which involves the serial application of three or more stages of selected reaction monitoring.		Roepstorff, Fohlman. Biomed. Mass Spectrom. 11, 601 (1984).