View source for CAD vs. CID

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===First posted ''January 21, 2005''===
:''See [[collision-induced dissociation]]''.

A search for occurrences <nowiki>[</nowiki>in 2005<nowiki>]</nowiki> of the two terms in the literature reveals a distinct preference. 

Collision-induced dissociation (CID) and collisionally activated dissociation (CAD) refer to the process in which a collision between and ion and a neutral species results in the conversion of part of the translational energy into internal energy of the ion and subsequent fragmentation. The IUPAC document defines the two terms equivalently as does Price (JASMS, 2, 336, 1991). The ASMS Terms and Definitions document does not mention CAD. Sparkman defines CAD and CID equivalently, but notes his preference for CAD.

[[Image:CID CAD.gif|center]]

A search of the literature for "collision induced dissociation" and "collisionally activated dissociation" suggests that the former term is preferred. In Figure 1, the number of occurrences of the above strings in journal articles is plotted as a function of the year of publication. The plot shows a clear preference for CID over CAD that increases after 1990. This trend can be seen clearly in Figure 2. The occurrence ratio is about 5 in the 80s and early 90s, then jumps to about 30 in the late 90s.

[[Image:CID CAD ratio.gif|center]]

Based on this data, should the IUPAC document list collision induced dissociation/CID as the preferred term?

[[Category:Comment]]
[[Category:Fragmentation]]
[[Category:Controversial terms]]